Wroblewski JT - Search Results

1

Synthesis and structure-activity relationships of 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine analogues as potent, noncompetitive metabotropic glutamate receptor subtype 5 antagonists; search for cocaine medications.

Iso Y, Grajkowska E, Wroblewski JT, Davis J, Goeders NE, Johnson KM, Sanker S, Roth BL, Tueckmantel W, Kozikowski AP. Iso Y, et al. Among authors: wroblewski jt. J Med Chem. 2006 Feb 9;49(3):1080-100. doi: 10.1021/jm050570f. J Med Chem. 2006. PMID: 16451073

2

Synthesis of urea-based inhibitors as active site probes of glutamate carboxypeptidase II: efficacy as analgesic agents.

Kozikowski AP, Zhang J, Nan F, Petukhov PA, Grajkowska E, Wroblewski JT, Yamamoto T, Bzdega T, Wroblewska B, Neale JH. Kozikowski AP, et al. Among authors: wroblewski jt. J Med Chem. 2004 Mar 25;47(7):1729-38. doi: 10.1021/jm0306226. J Med Chem. 2004. PMID: 15027864

3

Synthesis and receptor assay of aromatic-ethynyl-aromatic derivatives with potent mGluR5 antagonist activity.

Alagille D, Baldwin RM, Roth BL, Wroblewski JT, Grajkowska E, Tamagnan GD. Alagille D, et al. Among authors: wroblewski jt. Bioorg Med Chem. 2005 Jan 3;13(1):197-209. doi: 10.1016/j.bmc.2004.09.042. Bioorg Med Chem. 2005. PMID: 15582465

4

Synthesis and metabotropic glutamate receptor activity of a 2-aminobicyclo[3.2.0]heptane-2,5-dicarboxylic acid, a molecule possessing an extended glutamate conformation.

Kozikowski AP, Araldi GL, Flippen-Anderson J, George C, Pshenichkin S, Surina E, Wroblewski J. Kozikowski AP, et al. Bioorg Med Chem Lett. 1998 Apr 21;8(8):925-30. doi: 10.1016/s0960-894x(98)00146-2. Bioorg Med Chem Lett. 1998. PMID: 9871513 Free article.

5

alpha-substituted quisqualic acid analogs: new metabotropic glutamate receptor group II selective antagonists.

Kozikowski AP, Steensma D, Varasi M, Pshenichkin S, Surina E, Wroblewski JT. Kozikowski AP, et al. Among authors: wroblewski jt. Bioorg Med Chem Lett. 1998 Mar 3;8(5):447-52. doi: 10.1016/s0960-894x(98)00052-3. Bioorg Med Chem Lett. 1998. PMID: 9871596 Free article.

6

Synthesis of N(1)-substituted analogues of (2R,4R)-4-amino-pyrrolidine-2,4-dicarboxylic acid as agonists, partial agonists, and antagonists of group II metabotropic glutamate receptors.

Mukhopadhyaya JK, Kozikowski AP, Grajkowska E, Pshenichkin S, Wroblewski JT. Mukhopadhyaya JK, et al. Among authors: wroblewski jt. Bioorg Med Chem Lett. 2001 Jul 23;11(14):1919-24. doi: 10.1016/s0960-894x(01)00329-8. Bioorg Med Chem Lett. 2001. PMID: 11459661

7

Molecular modeling of the interactions of glutamate carboxypeptidase II with its potent NAAG-based inhibitors.

Rong SB, Zhang J, Neale JH, Wroblewski JT, Wang S, Kozikowski AP. Rong SB, et al. Among authors: wroblewski jt. J Med Chem. 2002 Sep 12;45(19):4140-52. doi: 10.1021/jm010561g. J Med Chem. 2002. PMID: 12213057

8

Functionalization at position 3 of the phenyl ring of the potent mGluR5 noncompetitive antagonists MPEP.

Alagille D, Baldwin RM, Roth BL, Wroblewski JT, Grajkowska E, Tamagnan GD. Alagille D, et al. Among authors: wroblewski jt. Bioorg Med Chem Lett. 2005 Feb 15;15(4):945-9. doi: 10.1016/j.bmcl.2004.12.047. Bioorg Med Chem Lett. 2005. PMID: 15686891

9

Synthesis and biology of the conformationally restricted ACPD analogue, 2-aminobicyclo[2.1.1]hexane-2,5-dicarboxylic acid-I, a potent mGluR agonist.

Kozikowski AP, Steensma D, Araldi GL, Tückmantel W, Wang S, Pshenichkin S, Surina E, Wroblewski JT. Kozikowski AP, et al. Among authors: wroblewski jt. J Med Chem. 1998 May 7;41(10):1641-50. doi: 10.1021/jm970719q. J Med Chem. 1998. PMID: 9572889

10

Synthesis and biological evaluation of two analogues of (S)-alpha-methyl-3-carboxyphenylalanine.

Ma D, Ma Z, Kozikowski AP, Pshenichkin S, Wroblewski JT. Ma D, et al. Among authors: wroblewski jt. Bioorg Med Chem Lett. 1998 Sep 22;8(18):2447-50. doi: 10.1016/s0960-894x(98)00409-0. Bioorg Med Chem Lett. 1998. PMID: 9873559 Free article.

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