Heitman LH - Search Results

1

Allosteric modulation, thermodynamics and binding to wild-type and mutant (T277A) adenosine A1 receptors of LUF5831, a novel nonadenosine-like agonist.

Heitman LH, Mulder-Krieger T, Spanjersberg RF, von Frijtag Drabbe Künzel JK, Dalpiaz A, IJzerman AP. Heitman LH, et al. Br J Pharmacol. 2006 Mar;147(5):533-41. doi: 10.1038/sj.bjp.0706655. Br J Pharmacol. 2006. PMID: 16444290 Free PMC article.

2

The 17^th EFMC Short Course on Medicinal Chemistry on Small Molecule Protein Degraders.

Ciulli A, O'Connor S, Chung CW, Hartung IV, Testa A, Daniels DL, Heitman LH. Ciulli A, et al. Among authors: heitman lh. ChemMedChem. 2023 Oct 17;18(20):e202300464. doi: 10.1002/cmdc.202300464. Epub 2023 Oct 10. ChemMedChem. 2023. PMID: 37817354

3

Synthesis and biological evaluation of 2,3,5-substituted [1,2,4]thiadiazoles as allosteric modulators of adenosine receptors.

van den Nieuwendijk AM, Pietra D, Heitman L, Göblyös A, IJzerman AP. van den Nieuwendijk AM, et al. J Med Chem. 2004 Jan 29;47(3):663-72. doi: 10.1021/jm030863d. J Med Chem. 2004. PMID: 14736246

4

[3H]Org 43553, the first low-molecular-weight agonistic and allosteric radioligand for the human luteinizing hormone receptor.

Heitman LH, Oosterom J, Bonger KM, Timmers CM, Wiegerinck PH, Ijzerman AP. Heitman LH, et al. Mol Pharmacol. 2008 Feb;73(2):518-24. doi: 10.1124/mol.107.039875. Epub 2007 Nov 7. Mol Pharmacol. 2008. PMID: 17989351

5

Amiloride derivatives and a nonpeptidic antagonist bind at two distinct allosteric sites in the human gonadotropin-releasing hormone receptor.

Heitman LH, Ye K, Oosterom J, Ijzerman AP. Heitman LH, et al. Mol Pharmacol. 2008 Jun;73(6):1808-15. doi: 10.1124/mol.107.043521. Epub 2008 Mar 14. Mol Pharmacol. 2008. PMID: 18344315

6

G protein-coupled receptors of the hypothalamic-pituitary-gonadal axis: a case for Gnrh, LH, FSH, and GPR54 receptor ligands.

Heitman LH, Ijzerman AP. Heitman LH, et al. Med Res Rev. 2008 Nov;28(6):975-1011. doi: 10.1002/med.20129. Med Res Rev. 2008. PMID: 18561294 Review.

7

False positives in a reporter gene assay: identification and synthesis of substituted N-pyridin-2-ylbenzamides as competitive inhibitors of firefly luciferase.

Heitman LH, van Veldhoven JP, Zweemer AM, Ye K, Brussee J, IJzerman AP. Heitman LH, et al. J Med Chem. 2008 Aug 14;51(15):4724-9. doi: 10.1021/jm8004509. Epub 2008 Jul 23. J Med Chem. 2008. PMID: 18646744

8

A series of 2,4-disubstituted quinolines as a new class of allosteric enhancers of the adenosine A3 receptor.

Heitman LH, Göblyös A, Zweemer AM, Bakker R, Mulder-Krieger T, van Veldhoven JP, de Vries H, Brussee J, Ijzerman AP. Heitman LH, et al. J Med Chem. 2009 Feb 26;52(4):926-31. doi: 10.1021/jm8014052. J Med Chem. 2009. PMID: 19161279

9

Substituted terphenyl compounds as the first class of low molecular weight allosteric inhibitors of the luteinizing hormone receptor.

Heitman LH, Narlawar R, de Vries H, Willemsen MN, Wolfram D, Brussee J, Ijzerman AP. Heitman LH, et al. J Med Chem. 2009 Apr 9;52(7):2036-42. doi: 10.1021/jm801561h. J Med Chem. 2009. PMID: 19296599

10

Determination of different putative allosteric binding pockets at the lutropin receptor by using diverse drug-like low molecular weight ligands.

Heitman LH, Kleinau G, Brussee J, Krause G, Ijzerman AP. Heitman LH, et al. Mol Cell Endocrinol. 2012 Apr 4;351(2):326-36. doi: 10.1016/j.mce.2012.01.010. Epub 2012 Jan 18. Mol Cell Endocrinol. 2012. PMID: 22269095

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