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A designed zinc-finger transcriptional repressor of phospholamban improves function of the failing heart.
Zhang HS, Liu D, Huang Y, Schmidt S, Hickey R, Guschin D, Su H, Jovin IS, Kunis M, Hinkley S, Liang Y, Hinh L, Spratt SK, Case CC, Rebar EJ, Ehrlich BE, Ehrlich B, Gregory PD, Giordano FJ. Zhang HS, et al. Among authors: rebar ej. Mol Ther. 2012 Aug;20(8):1508-15. doi: 10.1038/mt.2012.80. Epub 2012 Jul 24. Mol Ther. 2012. PMID: 22828502 Free PMC article.
Engineered zinc finger-activating vascular endothelial growth factor transcription factor plasmid DNA induces therapeutic angiogenesis in rabbits with hindlimb ischemia.
Dai Q, Huang J, Klitzman B, Dong C, Goldschmidt-Clermont PJ, March KL, Rokovich J, Johnstone B, Rebar EJ, Spratt SK, Case CC, Kontos CD, Annex BH. Dai Q, et al. Circulation. 2004 Oct 19;110(16):2467-75. doi: 10.1161/01.CIR.0000145139.53840.49. Epub 2004 Oct 11. Circulation. 2004. PMID: 15477407
Enhanced protein production by engineered zinc finger proteins.
Reik A, Zhou Y, Collingwood TN, Warfe L, Bartsevich V, Kong Y, Henning KA, Fallentine BK, Zhang L, Zhong X, Jouvenot Y, Jamieson AC, Rebar EJ, Case CC, Korman A, Li XY, Black A, King DJ, Gregory PD. Reik A, et al. Biotechnol Bioeng. 2007 Aug 1;97(5):1180-9. doi: 10.1002/bit.21304. Biotechnol Bioeng. 2007. PMID: 17171718
Regulation of an endogenous locus using a panel of designed zinc finger proteins targeted to accessible chromatin regions. Activation of vascular endothelial growth factor A.
Liu PQ, Rebar EJ, Zhang L, Liu Q, Jamieson AC, Liang Y, Qi H, Li PX, Chen B, Mendel MC, Zhong X, Lee YL, Eisenberg SP, Spratt SK, Case CC, Wolffe AP. Liu PQ, et al. Among authors: rebar ej. J Biol Chem. 2001 Apr 6;276(14):11323-34. doi: 10.1074/jbc.M011172200. Epub 2001 Jan 5. J Biol Chem. 2001. PMID: 11145970 Free article.
66 results