Newton DJ - Search Results

1

Characterization of mice lacking the multidrug resistance protein MRP2 (ABCC2).

Chu XY, Strauss JR, Mariano MA, Li J, Newton DJ, Cai X, Wang RW, Yabut J, Hartley DP, Evans DC, Evers R. Chu XY, et al. Among authors: newton dj. J Pharmacol Exp Ther. 2006 May;317(2):579-89. doi: 10.1124/jpet.105.098665. Epub 2006 Jan 18. J Pharmacol Exp Ther. 2006. PMID: 16421286

2

Evaluation of cynomolgus monkeys for the identification of endogenous biomarkers for hepatic transporter inhibition and as a translatable model to predict pharmacokinetic interactions with statins in humans.

Chu X, Shih SJ, Shaw R, Hentze H, Chan GH, Owens K, Wang S, Cai X, Newton D, Castro-Perez J, Salituro G, Palamanda J, Fernandis A, Ng CK, Liaw A, Savage MJ, Evers R. Chu X, et al. Drug Metab Dispos. 2015 Jun;43(6):851-63. doi: 10.1124/dmd.115.063347. Epub 2015 Mar 26. Drug Metab Dispos. 2015. PMID: 25813937

3

Determination of phase I metabolic enzyme activities in liver microsomes of Mrp2 deficient TR- and EHBR rats.

Newton DJ, Wang RW, Evans DC. Newton DJ, et al. Life Sci. 2005 Jul 22;77(10):1106-15. doi: 10.1016/j.lfs.2005.01.020. Life Sci. 2005. PMID: 15913659

4

Cytochrome P450 3A4 is the major enzyme involved in the metabolism of the substance P receptor antagonist aprepitant.

Sanchez RI, Wang RW, Newton DJ, Bakhtiar R, Lu P, Chiu SH, Evans DC, Huskey SE. Sanchez RI, et al. Among authors: newton dj. Drug Metab Dispos. 2004 Nov;32(11):1287-92. doi: 10.1124/dmd.104.000216. Epub 2004 Aug 10. Drug Metab Dispos. 2004. PMID: 15304427

5

Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.

Newton DJ, Wang RW, Lu AY. Newton DJ, et al. Drug Metab Dispos. 1995 Jan;23(1):154-8. Drug Metab Dispos. 1995. PMID: 7720520

6

Human cytochrome P450 3A4-catalyzed testosterone 6 beta-hydroxylation and erythromycin N-demethylation. Competition during catalysis.

Wang RW, Newton DJ, Scheri TD, Lu AY. Wang RW, et al. Among authors: newton dj. Drug Metab Dispos. 1997 Apr;25(4):502-7. Drug Metab Dispos. 1997. PMID: 9107550

7

Human cytochrome P-450 3A4: in vitro drug-drug interaction patterns are substrate-dependent.

Wang RW, Newton DJ, Liu N, Atkins WM, Lu AY. Wang RW, et al. Among authors: newton dj. Drug Metab Dispos. 2000 Mar;28(3):360-6. Drug Metab Dispos. 2000. PMID: 10681383

8

FK 506 metabolism in human liver microsomes: investigation of the involvement of cytochrome P450 isozymes other than CYP3A4.

Karanam BV, Vincent SH, Newton DJ, Wang RW, Chiu SH. Karanam BV, et al. Among authors: newton dj. Drug Metab Dispos. 1994 Sep-Oct;22(5):811-4. Drug Metab Dispos. 1994. PMID: 7530623 No abstract available.

9

Site-directed mutagenesis of glutathione S-transferase YaYa: nonessential role of histidine in catalysis.

Wang RW, Newton DJ, Pickett CB, Lu AY. Wang RW, et al. Among authors: newton dj. Arch Biochem Biophys. 1991 May 1;286(2):574-8. doi: 10.1016/0003-9861(91)90082-t. Arch Biochem Biophys. 1991. PMID: 1897979

10

Site-directed mutagenesis of glutathione S-transferase YaYa: functional studies of histidine, cysteine, and tryptophan mutants.

Wang RW, Newton DJ, Pickett CB, Lu AY. Wang RW, et al. Among authors: newton dj. Arch Biochem Biophys. 1992 Aug 15;297(1):86-91. doi: 10.1016/0003-9861(92)90644-c. Arch Biochem Biophys. 1992. PMID: 1637185

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