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The proteolytic activity of the paracaspase MALT1 is key in T cell activation.
Rebeaud F, Hailfinger S, Posevitz-Fejfar A, Tapernoux M, Moser R, Rueda D, Gaide O, Guzzardi M, Iancu EM, Rufer N, Fasel N, Thome M. Rebeaud F, et al. Among authors: tapernoux m. Nat Immunol. 2008 Mar;9(3):272-81. doi: 10.1038/ni1568. Epub 2008 Feb 10. Nat Immunol. 2008. PMID: 18264101
Phosphorylation of CARMA1 by HPK1 is critical for NF-kappaB activation in T cells.
Brenner D, Brechmann M, Röhling S, Tapernoux M, Mock T, Winter D, Lehmann WD, Kiefer F, Thome M, Krammer PH, Arnold R. Brenner D, et al. Among authors: tapernoux m. Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14508-13. doi: 10.1073/pnas.0900457106. Epub 2009 Aug 11. Proc Natl Acad Sci U S A. 2009. PMID: 19706536 Free PMC article.