Jalkanen A - Search Results

1

Binding kinetics and duration of in vivo action of novel prolyl oligopeptidase inhibitors.

Venäläinen JI, Garcia-Horsman JA, Forsberg MM, Jalkanen A, Wallén EA, Jarho EM, Christiaans JA, Gynther J, Männistö PT. Venäläinen JI, et al. Among authors: jalkanen a. Biochem Pharmacol. 2006 Feb 28;71(5):683-92. doi: 10.1016/j.bcp.2005.11.029. Epub 2006 Jan 6. Biochem Pharmacol. 2006. PMID: 16405869

2

Beneficial effect of prolyl oligopeptidase inhibition on spatial memory in young but not in old scopolamine-treated rats.

Jalkanen AJ, Puttonen KA, Venäläinen JI, Sinervä V, Mannila A, Ruotsalainen S, Jarho EM, Wallén EA, Männistö PT. Jalkanen AJ, et al. Basic Clin Pharmacol Toxicol. 2007 Feb;100(2):132-8. doi: 10.1111/j.1742-7843.2006.00021.x. Basic Clin Pharmacol Toxicol. 2007. PMID: 17244263 Free article.

3

Prolyl oligopeptidase: a potential target for the treatment of cognitive disorders.

Männisto PT, Venäläinen J, Jalkanen A, García-Horsman JA. Männisto PT, et al. Among authors: jalkanen a. Drug News Perspect. 2007 Jun;20(5):293-305. doi: 10.1358/dnp.2007.20.5.1120216. Drug News Perspect. 2007. PMID: 17878957 Free article. Review.

4

Localization of prolyl oligopeptidase in the thalamic and cortical projection neurons: a retrograde neurotracing study in the rat brain.

Myöhänen TT, Kääriäinen TM, Jalkanen AJ, Piltonen M, Männistö PT. Myöhänen TT, et al. Neurosci Lett. 2009 Jan 30;450(2):201-5. doi: 10.1016/j.neulet.2008.11.038. Epub 2008 Nov 21. Neurosci Lett. 2009. PMID: 19041368

5

Different effects of scopolamine and inhibition of prolyl oligopeptidase on mnemonic and motility functions of young and 8- to 9-month-old rats in the radial-arm maze.

Peltonen I, Jalkanen AJ, Sinervä V, Puttonen KA, Männistö PT. Peltonen I, et al. Among authors: jalkanen aj. Basic Clin Pharmacol Toxicol. 2010 Apr;106(4):280-7. doi: 10.1111/j.1742-7843.2009.00484.x. Epub 2009 Nov 11. Basic Clin Pharmacol Toxicol. 2010. PMID: 20041878 Free article.

6

Brain uptake of ketoprofen-lysine prodrug in rats.

Gynther M, Jalkanen A, Lehtonen M, Forsberg M, Laine K, Ropponen J, Leppänen J, Knuuti J, Rautio J. Gynther M, et al. Among authors: jalkanen a. Int J Pharm. 2010 Oct 31;399(1-2):121-8. doi: 10.1016/j.ijpharm.2010.08.019. Epub 2010 Aug 19. Int J Pharm. 2010. PMID: 20727958

7

Comparison of in vitro cell models in predicting in vivo brain entry of drugs.

Hakkarainen JJ, Jalkanen AJ, Kääriäinen TM, Keski-Rahkonen P, Venäläinen T, Hokkanen J, Mönkkönen J, Suhonen M, Forsberg MM. Hakkarainen JJ, et al. Int J Pharm. 2010 Dec 15;402(1-2):27-36. doi: 10.1016/j.ijpharm.2010.09.016. Epub 2010 Oct 8. Int J Pharm. 2010. PMID: 20920560

8

Brain pharmacokinetics of two prolyl oligopeptidase inhibitors, JTP-4819 and KYP-2047, in the rat.

Jalkanen AJ, Hakkarainen JJ, Lehtonen M, Venäläinen T, Kääriäinen TM, Jarho E, Suhonen M, Forsberg MM. Jalkanen AJ, et al. Basic Clin Pharmacol Toxicol. 2011 Dec;109(6):443-51. doi: 10.1111/j.1742-7843.2011.00747.x. Epub 2011 Jul 28. Basic Clin Pharmacol Toxicol. 2011. PMID: 21707925 Free article.

9

Inhibition of prolyl oligopeptidase by KYP-2047 fails to increase the extracellular neurotensin and substance P levels in rat striatum.

Jalkanen AJ, Savolainen K, Forsberg MM. Jalkanen AJ, et al. Neurosci Lett. 2011 Sep 15;502(2):107-11. doi: 10.1016/j.neulet.2011.07.033. Epub 2011 Jul 29. Neurosci Lett. 2011. PMID: 21820035

10

The effect of prolyl oligopeptidase inhibition on extracellular acetylcholine and dopamine levels in the rat striatum.

Jalkanen AJ, Piepponen TP, Hakkarainen JJ, De Meester I, Lambeir AM, Forsberg MM. Jalkanen AJ, et al. Neurochem Int. 2012 Feb;60(3):301-9. doi: 10.1016/j.neuint.2011.12.010. Epub 2011 Dec 22. Neurochem Int. 2012. PMID: 22210165

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