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1-(3',4'-Dichloro-2-fluoro[1,1'-biphenyl]-4-yl)-cyclopropanecarboxylic acid (CHF5074), a novel gamma-secretase modulator, reduces brain beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease without causing peripheral toxicity.
Imbimbo BP, Del Giudice E, Colavito D, D'Arrigo A, Dalle Carbonare M, Villetti G, Facchinetti F, Volta R, Pietrini V, Baroc MF, Serneels L, De Strooper B, Leon A. Imbimbo BP, et al. Among authors: leon a. J Pharmacol Exp Ther. 2007 Dec;323(3):822-30. doi: 10.1124/jpet.107.129007. Epub 2007 Sep 25. J Pharmacol Exp Ther. 2007. PMID: 17895400
Neurotrophic factors in the therapy of Parkinson's disease.
Facchinetti F, Terrazzino S, D'Arrigo A, Rinaldi L, Leon A. Facchinetti F, et al. Among authors: leon a. Funct Neurol. 2001 Jan-Mar;16(1):45-56. Funct Neurol. 2001. PMID: 11396271 Review. No abstract available.
2,452 results