Leach MO - Search Results

1

Noninvasive magnetic resonance spectroscopic pharmacodynamic markers of the choline kinase inhibitor MN58b in human carcinoma models.

Al-Saffar NM, Troy H, Ramírez de Molina A, Jackson LE, Madhu B, Griffiths JR, Leach MO, Workman P, Lacal JC, Judson IR, Chung YL. Al-Saffar NM, et al. Among authors: leach mo. Cancer Res. 2006 Jan 1;66(1):427-34. doi: 10.1158/0008-5472.CAN-05-1338. Cancer Res. 2006. PMID: 16397258

2

Potential role of magnetic resonance spectroscopy in assessment of tumour response in childhood cancer.

Vaidya SJ, Payne GS, Leach MO, Pinkerton CR. Vaidya SJ, et al. Among authors: leach mo. Eur J Cancer. 2003 Apr;39(6):728-35. doi: 10.1016/s0959-8049(02)00728-1. Eur J Cancer. 2003. PMID: 12651196 Review.

3

Magnetic resonance spectroscopic pharmacodynamic markers of the heat shock protein 90 inhibitor 17-allylamino,17-demethoxygeldanamycin (17AAG) in human colon cancer models.

Chung YL, Troy H, Banerji U, Jackson LE, Walton MI, Stubbs M, Griffiths JR, Judson IR, Leach MO, Workman P, Ronen SM. Chung YL, et al. Among authors: leach mo. J Natl Cancer Inst. 2003 Nov 5;95(21):1624-33. doi: 10.1093/jnci/djg084. J Natl Cancer Inst. 2003. PMID: 14600095

4

A phase I study of SR-4554 via intravenous administration for noninvasive investigation of tumor hypoxia by magnetic resonance spectroscopy in patients with malignancy.

Seddon BM, Payne GS, Simmons L, Ruddle R, Grimshaw R, Tan S, Turner A, Raynaud F, Halbert G, Leach MO, Judson I, Workman P. Seddon BM, et al. Among authors: leach mo. Clin Cancer Res. 2003 Nov 1;9(14):5101-12. Clin Cancer Res. 2003. PMID: 14613987 Review.

5

Noninvasive measurements of capecitabine metabolism in bladder tumors overexpressing thymidine phosphorylase by fluorine-19 magnetic resonance spectroscopy.

Chung YL, Troy H, Judson IR, Leek R, Leach MO, Stubbs M, Harris AL, Griffiths JR. Chung YL, et al. Among authors: leach mo. Clin Cancer Res. 2004 Jun 1;10(11):3863-70. doi: 10.1158/1078-0432.CCR-03-0237. Clin Cancer Res. 2004. PMID: 15173095

6

Magnetic resonance spectroscopy monitoring of mitogen-activated protein kinase signaling inhibition.

Beloueche-Babari M, Jackson LE, Al-Saffar NM, Workman P, Leach MO, Ronen SM. Beloueche-Babari M, et al. Among authors: leach mo. Cancer Res. 2005 Apr 15;65(8):3356-63. doi: 10.1158/10.1158/0008-5472.CAN-03-2981. Cancer Res. 2005. PMID: 15833869

7

Identification of biliary metabolites of ifosfamide using 31P magnetic resonance spectroscopy and mass spectrometry.

Payne GS, Dzik-Jurasz AS, Mancini L, Nutley B, Raynaud F, Leach MO. Payne GS, et al. Among authors: leach mo. Cancer Chemother Pharmacol. 2005 Oct;56(4):409-14. doi: 10.1007/s00280-005-1023-2. Epub 2005 May 5. Cancer Chemother Pharmacol. 2005. PMID: 15877229

8

Implementation and evaluation of CSI-localized J cross-polarization for detection of 31P magnetic resonance spectra in vivo.

Mancini L, Payne GS, Leach MO. Mancini L, et al. Among authors: leach mo. Magn Reson Med. 2005 Nov;54(5):1065-71. doi: 10.1002/mrm.20659. Magn Reson Med. 2005. PMID: 16200551 Free article. Clinical Trial.

9

A Phase I study of the angiogenesis inhibitor SU5416 (semaxanib) in solid tumours, incorporating dynamic contrast MR pharmacodynamic end points.

O'Donnell A, Padhani A, Hayes C, Kakkar AJ, Leach M, Trigo JM, Scurr M, Raynaud F, Phillips S, Aherne W, Hardcastle A, Workman P, Hannah A, Judson I. O'Donnell A, et al. Br J Cancer. 2005 Oct 17;93(8):876-83. doi: 10.1038/sj.bjc.6602797. Br J Cancer. 2005. PMID: 16222321 Free PMC article. Clinical Trial.

10

Identification of magnetic resonance detectable metabolic changes associated with inhibition of phosphoinositide 3-kinase signaling in human breast cancer cells.

Beloueche-Babari M, Jackson LE, Al-Saffar NM, Eccles SA, Raynaud FI, Workman P, Leach MO, Ronen SM. Beloueche-Babari M, et al. Among authors: leach mo. Mol Cancer Ther. 2006 Jan;5(1):187-96. doi: 10.1158/1535-7163.MCT-03-0220. Mol Cancer Ther. 2006. PMID: 16432178

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