Lacal JC - Search Results

1

Noninvasive magnetic resonance spectroscopic pharmacodynamic markers of the choline kinase inhibitor MN58b in human carcinoma models.

Al-Saffar NM, Troy H, Ramírez de Molina A, Jackson LE, Madhu B, Griffiths JR, Leach MO, Workman P, Lacal JC, Judson IR, Chung YL. Al-Saffar NM, et al. Among authors: lacal jc. Cancer Res. 2006 Jan 1;66(1):427-34. doi: 10.1158/0008-5472.CAN-05-1338. Cancer Res. 2006. PMID: 16397258

2

The phosphoinositide 3-kinase inhibitor PI-103 downregulates choline kinase alpha leading to phosphocholine and total choline decrease detected by magnetic resonance spectroscopy.

Al-Saffar NM, Jackson LE, Raynaud FI, Clarke PA, Ramírez de Molina A, Lacal JC, Workman P, Leach MO. Al-Saffar NM, et al. Among authors: lacal jc. Cancer Res. 2010 Jul 1;70(13):5507-17. doi: 10.1158/0008-5472.CAN-09-4476. Epub 2010 Jun 15. Cancer Res. 2010. PMID: 20551061 Free PMC article.

3

From Ras signalling to ChoK inhibitors: a further advance in anticancer drug design.

Ramírez de Molina A, Rodríguez-González A, Lacal JC. Ramírez de Molina A, et al. Among authors: lacal jc. Cancer Lett. 2004 Apr 8;206(2):137-48. doi: 10.1016/j.canlet.2003.08.031. Cancer Lett. 2004. PMID: 15013519 Review.

4

Choline kinase activation is a critical requirement for the proliferation of primary human mammary epithelial cells and breast tumor progression.

Ramírez de Molina A, Báñez-Coronel M, Gutiérrez R, Rodríguez-González A, Olmeda D, Megías D, Lacal JC. Ramírez de Molina A, et al. Among authors: lacal jc. Cancer Res. 2004 Sep 15;64(18):6732-9. doi: 10.1158/0008-5472.CAN-04-0489. Cancer Res. 2004. PMID: 15374991

5

Choline kinase is a novel oncogene that potentiates RhoA-induced carcinogenesis.

Ramírez de Molina A, Gallego-Ortega D, Sarmentero J, Bañez-Coronel M, Martín-Cantalejo Y, Lacal JC. Ramírez de Molina A, et al. Among authors: lacal jc. Cancer Res. 2005 Jul 1;65(13):5647-53. doi: 10.1158/0008-5472.CAN-04-4416. Cancer Res. 2005. PMID: 15994937

6

Regulation of Akt(ser473) phosphorylation by choline kinase in breast carcinoma cells.

Chua BT, Gallego-Ortega D, Ramirez de Molina A, Ullrich A, Lacal JC, Downward J. Chua BT, et al. Among authors: lacal jc. Mol Cancer. 2009 Dec 31;8:131. doi: 10.1186/1476-4598-8-131. Mol Cancer. 2009. PMID: 20042122 Free PMC article.

7

Overexpression of choline kinase is a frequent feature in human tumor-derived cell lines and in lung, prostate, and colorectal human cancers.

Ramírez de Molina A, Rodríguez-González A, Gutiérrez R, Martínez-Piñeiro L, Sánchez J, Bonilla F, Rosell R, Lacal J. Ramírez de Molina A, et al. Biochem Biophys Res Commun. 2002 Aug 23;296(3):580-3. doi: 10.1016/s0006-291x(02)00920-8. Biochem Biophys Res Commun. 2002. PMID: 12176020

8

Increased choline kinase activity in human breast carcinomas: clinical evidence for a potential novel antitumor strategy.

Ramírez de Molina A, Gutiérrez R, Ramos MA, Silva JM, Silva J, Bonilla F, Sánchez JJ, Lacal JC. Ramírez de Molina A, et al. Among authors: lacal jc. Oncogene. 2002 Jun 20;21(27):4317-22. doi: 10.1038/sj.onc.1205556. Oncogene. 2002. PMID: 12082619

9

Phospholipase D and choline kinase: their role in cancer development and their potential as drug targets.

Rodríguez-González A, Ramírez de Molina A, Benítez-Rajal J, Lacal JC. Rodríguez-González A, et al. Among authors: lacal jc. Prog Cell Cycle Res. 2003;5:191-201. Prog Cell Cycle Res. 2003. PMID: 14593713 Review.

10

Choline kinase inhibition induces the increase in ceramides resulting in a highly specific and selective cytotoxic antitumoral strategy as a potential mechanism of action.

Rodríguez-González A, Ramirez de Molina A, Fernández F, Lacal JC. Rodríguez-González A, et al. Among authors: lacal jc. Oncogene. 2004 Oct 28;23(50):8247-59. doi: 10.1038/sj.onc.1208045. Oncogene. 2004. PMID: 15378008

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