Al-Saffar NM - Search Results

1

Noninvasive magnetic resonance spectroscopic pharmacodynamic markers of the choline kinase inhibitor MN58b in human carcinoma models.

Al-Saffar NM, Troy H, Ramírez de Molina A, Jackson LE, Madhu B, Griffiths JR, Leach MO, Workman P, Lacal JC, Judson IR, Chung YL. Al-Saffar NM, et al. Cancer Res. 2006 Jan 1;66(1):427-34. doi: 10.1158/0008-5472.CAN-05-1338. Cancer Res. 2006. PMID: 16397258

2

Magnetic resonance spectroscopy monitoring of mitogen-activated protein kinase signaling inhibition.

Beloueche-Babari M, Jackson LE, Al-Saffar NM, Workman P, Leach MO, Ronen SM. Beloueche-Babari M, et al. Cancer Res. 2005 Apr 15;65(8):3356-63. doi: 10.1158/10.1158/0008-5472.CAN-03-2981. Cancer Res. 2005. PMID: 15833869

3

Identification of magnetic resonance detectable metabolic changes associated with inhibition of phosphoinositide 3-kinase signaling in human breast cancer cells.

Beloueche-Babari M, Jackson LE, Al-Saffar NM, Eccles SA, Raynaud FI, Workman P, Leach MO, Ronen SM. Beloueche-Babari M, et al. Among authors: al saffar nm. Mol Cancer Ther. 2006 Jan;5(1):187-96. doi: 10.1158/1535-7163.MCT-03-0220. Mol Cancer Ther. 2006. PMID: 16432178

4

The phosphoinositide 3-kinase inhibitor PI-103 downregulates choline kinase alpha leading to phosphocholine and total choline decrease detected by magnetic resonance spectroscopy.

Al-Saffar NM, Jackson LE, Raynaud FI, Clarke PA, Ramírez de Molina A, Lacal JC, Workman P, Leach MO. Al-Saffar NM, et al. Cancer Res. 2010 Jul 1;70(13):5507-17. doi: 10.1158/0008-5472.CAN-09-4476. Epub 2010 Jun 15. Cancer Res. 2010. PMID: 20551061 Free PMC article.

5

Metabolic biomarkers of response to the AKT inhibitor MK-2206 in pre-clinical models of human colorectal and prostate carcinoma.

Al-Saffar NMS, Troy H, Wong Te Fong AC, Paravati R, Jackson LE, Gowan S, Boult JKR, Robinson SP, Eccles SA, Yap TA, Leach MO, Chung YL. Al-Saffar NMS, et al. Br J Cancer. 2018 Oct;119(9):1118-1128. doi: 10.1038/s41416-018-0242-3. Epub 2018 Oct 31. Br J Cancer. 2018. PMID: 30377337 Free PMC article.

6

Metabolic assessment of the action of targeted cancer therapeutics using magnetic resonance spectroscopy.

Beloueche-Babari M, Chung YL, Al-Saffar NM, Falck-Miniotis M, Leach MO. Beloueche-Babari M, et al. Among authors: al saffar nm. Br J Cancer. 2010 Jan 5;102(1):1-7. doi: 10.1038/sj.bjc.6605457. Epub 2009 Nov 24. Br J Cancer. 2010. PMID: 19935796 Free PMC article. Review.

7

Effects of HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin (17-AAG) on NEU/HER2 overexpressing mammary tumours in MMTV-NEU-NT mice monitored by Magnetic Resonance Spectroscopy.

Rodrigues LM, Chung YL, Al Saffar NM, Sharp SY, Jackson LE, Banerji U, Stubbs M, Leach MO, Griffiths JR, Workman P. Rodrigues LM, et al. Among authors: al saffar nm. BMC Res Notes. 2012 May 23;5:250. doi: 10.1186/1756-0500-5-250. BMC Res Notes. 2012. PMID: 22621282 Free PMC article.

8

Model free approach to kinetic analysis of real-time hyperpolarized 13C magnetic resonance spectroscopy data.

Hill DK, Orton MR, Mariotti E, Boult JK, Panek R, Jafar M, Parkes HG, Jamin Y, Miniotis MF, Al-Saffar NM, Beloueche-Babari M, Robinson SP, Leach MO, Chung YL, Eykyn TR. Hill DK, et al. Among authors: al saffar nm. PLoS One. 2013 Sep 4;8(9):e71996. doi: 10.1371/journal.pone.0071996. eCollection 2013. PLoS One. 2013. PMID: 24023724 Free PMC article.

9

Lactate and choline metabolites detected in vitro by nuclear magnetic resonance spectroscopy are potential metabolic biomarkers for PI3K inhibition in pediatric glioblastoma.

Al-Saffar NM, Marshall LV, Jackson LE, Balarajah G, Eykyn TR, Agliano A, Clarke PA, Jones C, Workman P, Pearson AD, Leach MO. Al-Saffar NM, et al. PLoS One. 2014 Aug 1;9(8):e103835. doi: 10.1371/journal.pone.0103835. eCollection 2014. PLoS One. 2014. PMID: 25084455 Free PMC article.

10

Pediatric and adult glioblastoma radiosensitization induced by PI3K/mTOR inhibition causes early metabolic alterations detected by nuclear magnetic resonance spectroscopy.

Agliano A, Balarajah G, Ciobota DM, Sidhu J, Clarke PA, Jones C, Workman P, Leach MO, Al-Saffar NMS. Agliano A, et al. Among authors: al saffar nms. Oncotarget. 2017 Jul 18;8(29):47969-47983. doi: 10.18632/oncotarget.18206. Oncotarget. 2017. PMID: 28624789 Free PMC article.

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