Mohr K - Search Results

1

6H,13H-Pyrazino[1,2-a;4,5-a']diindole analogs: probing the pharmacophore for allosteric ligands of muscarinic M2 receptors.

Zlotos DP, Tränkle C, Abdelrahman A, Gündisch D, Radacki K, Braunschweig H, Mohr K. Zlotos DP, et al. Among authors: mohr k. Bioorg Med Chem Lett. 2006 Mar 15;16(6):1481-5. doi: 10.1016/j.bmcl.2005.12.030. Epub 2006 Jan 4. Bioorg Med Chem Lett. 2006. PMID: 16387499

2

Probing the pharmacophore for allosteric ligands of muscarinic M2 receptors: SAR and QSAR studies in a series of bisquaternary salts of caracurine V and related ring systems.

Zlotos DP, Buller S, Stiefl N, Baumann K, Mohr K. Zlotos DP, et al. Among authors: mohr k. J Med Chem. 2004 Jul 1;47(14):3561-71. doi: 10.1021/jm0311341. J Med Chem. 2004. PMID: 15214783

3

First gallamine-tacrine hybrid: design and characterization at cholinesterases and the M2 muscarinic receptor.

Elsinghorst PW, Cieslik JS, Mohr K, Tränkle C, Gütschow M. Elsinghorst PW, et al. Among authors: mohr k. J Med Chem. 2007 Nov 15;50(23):5685-95. doi: 10.1021/jm070859s. Epub 2007 Oct 18. J Med Chem. 2007. PMID: 17944454

4

A hydrazide linker strategy for heterobivalent compounds as ortho- and allosteric ligands of acetylcholine-binding proteins.

Elsinghorst PW, Härtig W, Gündisch D, Mohr K, Tränkle C, Gütschow M. Elsinghorst PW, et al. Among authors: mohr k. Curr Top Med Chem. 2011 Nov;11(22):2731-48. doi: 10.2174/156802611798184427. Curr Top Med Chem. 2011. PMID: 22039876 Review.

5

Dualsteric muscarinic antagonists--orthosteric binding pose controls allosteric subtype selectivity.

Schmitz J, van der Mey D, Bermudez M, Klöckner J, Schrage R, Kostenis E, Tränkle C, Wolber G, Mohr K, Holzgrabe U. Schmitz J, et al. Among authors: mohr k. J Med Chem. 2014 Aug 14;57(15):6739-50. doi: 10.1021/jm500790x. Epub 2014 Aug 4. J Med Chem. 2014. PMID: 25051097

6

Rational design of partial agonists for the muscarinic m1 acetylcholine receptor.

Chen X, Klöckner J, Holze J, Zimmermann C, Seemann WK, Schrage R, Bock A, Mohr K, Tränkle C, Holzgrabe U, Decker M. Chen X, et al. Among authors: mohr k. J Med Chem. 2015 Jan 22;58(2):560-76. doi: 10.1021/jm500860w. Epub 2014 Dec 19. J Med Chem. 2015. PMID: 25478907

7

Systematic development of high affinity bis(ammonio)alkane-type allosteric enhancers of muscarinic ligand binding.

Muth M, Bender W, Scharfenstein O, Holzgrabe U, Balatkova E, Tränkle C, Mohr K. Muth M, et al. Among authors: mohr k. J Med Chem. 2003 Mar 13;46(6):1031-40. doi: 10.1021/jm021017q. J Med Chem. 2003. PMID: 12620079

8

Bisquaternary ligands of the common allosteric site of M2 acetylcholine receptors: search for the minimum essential distances between the pharmacophoric elements.

Nassif-Makki T, Tränkle C, Zlotos D, Bejeuhr G, Cambareri A, Pfletschinger C, Kostenis E, Mohr K, Holzgrabe U. Nassif-Makki T, et al. Among authors: mohr k. J Med Chem. 1999 Mar 11;42(5):849-58. doi: 10.1021/jm981023f. J Med Chem. 1999. PMID: 10072682

9

Probing the size of a hydrophobic binding pocket within the allosteric site of muscarinic acetylcholine M2-receptors.

Bender W, Staudt M, Tränkle C, Mohr K, Holzgrabe U. Bender W, et al. Among authors: mohr k. Life Sci. 2000 Mar 24;66(18):1675-82. doi: 10.1016/s0024-3205(00)00490-2. Life Sci. 2000. PMID: 10809164

10

Structure-activity relationships in a series of bisquaternary bisphthalimidine derivatives modulating the muscarinic M(2)-receptor allosterically.

Botero Cid HM, Tränkle C, Baumann K, Pick R, Mies-Klomfass E, Kostenis E, Mohr K, Holzgrabe U. Botero Cid HM, et al. Among authors: mohr k. J Med Chem. 2000 Jun 1;43(11):2155-64. doi: 10.1021/jm991136e. J Med Chem. 2000. PMID: 10841794

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