Tyndall JD - Search Results

1

Mode of binding of methyl acceptor substrates to the adrenaline-synthesizing enzyme phenylethanolamine N-methyltransferase: implications for catalysis.

Gee CL, Tyndall JD, Grunewald GL, Wu Q, McLeish MJ, Martin JL. Gee CL, et al. Among authors: tyndall jd. Biochemistry. 2005 Dec 27;44(51):16875-85. doi: 10.1021/bi051636b. Biochemistry. 2005. PMID: 16363801

2

Disulfide-linked dimers of human adrenaline synthesizing enzyme PNMT are catalytically active.

Gee CL, Nourse A, Hsin AY, Wu Q, Tyndall JD, Grunewald GL, McLeish MJ, Martin JL. Gee CL, et al. Among authors: tyndall jd. Biochim Biophys Acta. 2005 Jun 15;1750(1):82-92. doi: 10.1016/j.bbapap.2005.03.006. Epub 2005 Apr 2. Biochim Biophys Acta. 2005. PMID: 15893506

3

Structural, mutagenic, and kinetic analysis of the binding of substrates and inhibitors of human phenylethanolamine N-methyltransferase.

Wu Q, Gee CL, Lin F, Tyndall JD, Martin JL, Grunewald GL, McLeish MJ. Wu Q, et al. Among authors: tyndall jd. J Med Chem. 2005 Nov 17;48(23):7243-52. doi: 10.1021/jm050568o. J Med Chem. 2005. PMID: 16279783

4

Enzyme adaptation to inhibitor binding: a cryptic binding site in phenylethanolamine N-methyltransferase.

Gee CL, Drinkwater N, Tyndall JD, Grunewald GL, Wu Q, McLeish MJ, Martin JL. Gee CL, et al. Among authors: tyndall jd. J Med Chem. 2007 Oct 4;50(20):4845-53. doi: 10.1021/jm0703385. Epub 2007 Sep 11. J Med Chem. 2007. PMID: 17845018

5

Countering cooperative effects in protease inhibitors using constrained beta-strand-mimicking templates in focused combinatorial libraries.

Reid RC, Pattenden LK, Tyndall JD, Martin JL, Walsh T, Fairlie DP. Reid RC, et al. Among authors: tyndall jd. J Med Chem. 2004 Mar 25;47(7):1641-51. doi: 10.1021/jm030337m. J Med Chem. 2004. PMID: 15027855

6

Crystal structures of highly constrained substrate and hydrolysis products bound to HIV-1 protease. Implications for the catalytic mechanism.

Tyndall JD, Pattenden LK, Reid RC, Hu SH, Alewood D, Alewood PF, Walsh T, Fairlie DP, Martin JL. Tyndall JD, et al. Biochemistry. 2008 Mar 25;47(12):3736-44. doi: 10.1021/bi7023157. Epub 2008 Mar 1. Biochemistry. 2008. PMID: 18311928

7

D-Tyrosine as a chiral precusor to potent inhibitors of human nonpancreatic secretory phospholipase A2 (IIa) with antiinflammatory activity.

Hansford KA, Reid RC, Clark CI, Tyndall JD, Whitehouse MW, Guthrie T, McGeary RP, Schafer K, Martin JL, Fairlie DP. Hansford KA, et al. Among authors: tyndall jd. Chembiochem. 2003 Mar 3;4(2-3):181-5. doi: 10.1002/cbic.200390029. Chembiochem. 2003. PMID: 12616631

8

Synthesis, stability, antiviral activity, and protease-bound structures of substrate-mimicking constrained macrocyclic inhibitors of HIV-1 protease.

Tyndall JD, Reid RC, Tyssen DP, Jardine DK, Todd B, Passmore M, March DR, Pattenden LK, Bergman DA, Alewood D, Hu SH, Alewood PF, Birch CJ, Martin JL, Fairlie DP. Tyndall JD, et al. J Med Chem. 2000 Sep 21;43(19):3495-504. doi: 10.1021/jm000013n. J Med Chem. 2000. PMID: 11000004

9

Site-directed mutagenesis and kinetic studies of the West Nile Virus NS3 protease identify key enzyme-substrate interactions.

Chappell KJ, Nall TA, Stoermer MJ, Fang NX, Tyndall JD, Fairlie DP, Young PR. Chappell KJ, et al. Among authors: tyndall jd. J Biol Chem. 2005 Jan 28;280(4):2896-903. doi: 10.1074/jbc.M409931200. Epub 2004 Oct 19. J Biol Chem. 2005. PMID: 15494419 Free article.

10

Formation of mononuclear and chloro-bridged binuclear copper(II) complexes of patellamide D, a naturally occurring cyclic peptide: influence of anion and solvent.

van den Brenk AL, Tyndall JD, Cusack RM, Jones A, Fairlie DP, Gahan LR, Hanson GR. van den Brenk AL, et al. Among authors: tyndall jd. J Inorg Biochem. 2004 Nov;98(11):1857-66. doi: 10.1016/j.jinorgbio.2004.08.005. J Inorg Biochem. 2004. PMID: 15522413

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