McLeish MJ - Search Results

1

Mode of binding of methyl acceptor substrates to the adrenaline-synthesizing enzyme phenylethanolamine N-methyltransferase: implications for catalysis.

Gee CL, Tyndall JD, Grunewald GL, Wu Q, McLeish MJ, Martin JL. Gee CL, et al. Among authors: mcleish mj. Biochemistry. 2005 Dec 27;44(51):16875-85. doi: 10.1021/bi051636b. Biochemistry. 2005. PMID: 16363801

2

Crystallization of PNMT, the adrenaline-synthesizing enzyme, is critically dependent on a high protein concentration.

Begun J, McLeish MJ, Caine JM, Palant E, Grunewald GL, Martin JL. Begun J, et al. Among authors: mcleish mj. Acta Crystallogr D Biol Crystallogr. 2002 Feb;58(Pt 2):314-5. doi: 10.1107/s090744490101962x. Epub 2002 Jan 24. Acta Crystallogr D Biol Crystallogr. 2002. PMID: 11807261

3

Molecular recognition of sub-micromolar inhibitors by the epinephrine-synthesizing enzyme phenylethanolamine N-methyltransferase.

McMillan FM, Archbold J, McLeish MJ, Caine JM, Criscione KR, Grunewald GL, Martin JL. McMillan FM, et al. Among authors: mcleish mj. J Med Chem. 2004 Jan 1;47(1):37-44. doi: 10.1021/jm0205752. J Med Chem. 2004. PMID: 14695818

4

Disulfide-linked dimers of human adrenaline synthesizing enzyme PNMT are catalytically active.

Gee CL, Nourse A, Hsin AY, Wu Q, Tyndall JD, Grunewald GL, McLeish MJ, Martin JL. Gee CL, et al. Among authors: mcleish mj. Biochim Biophys Acta. 2005 Jun 15;1750(1):82-92. doi: 10.1016/j.bbapap.2005.03.006. Epub 2005 Apr 2. Biochim Biophys Acta. 2005. PMID: 15893506

5

Structural, mutagenic, and kinetic analysis of the binding of substrates and inhibitors of human phenylethanolamine N-methyltransferase.

Wu Q, Gee CL, Lin F, Tyndall JD, Martin JL, Grunewald GL, McLeish MJ. Wu Q, et al. Among authors: mcleish mj. J Med Chem. 2005 Nov 17;48(23):7243-52. doi: 10.1021/jm050568o. J Med Chem. 2005. PMID: 16279783

6

Enzyme adaptation to inhibitor binding: a cryptic binding site in phenylethanolamine N-methyltransferase.

Gee CL, Drinkwater N, Tyndall JD, Grunewald GL, Wu Q, McLeish MJ, Martin JL. Gee CL, et al. Among authors: mcleish mj. J Med Chem. 2007 Oct 4;50(20):4845-53. doi: 10.1021/jm0703385. Epub 2007 Sep 11. J Med Chem. 2007. PMID: 17845018

7

Molecular recognition of physiological substrate noradrenaline by the adrenaline-synthesizing enzyme PNMT and factors influencing its methyltransferase activity.

Drinkwater N, Gee CL, Puri M, Criscione KR, McLeish MJ, Grunewald GL, Martin JL. Drinkwater N, et al. Among authors: mcleish mj. Biochem J. 2009 Aug 27;422(3):463-71. doi: 10.1042/BJ20090702. Biochem J. 2009. PMID: 19570037 Free PMC article.

8

Fragment-based screening by X-ray crystallography, MS and isothermal titration calorimetry to identify PNMT (phenylethanolamine N-methyltransferase) inhibitors.

Drinkwater N, Vu H, Lovell KM, Criscione KR, Collins BM, Prisinzano TE, Poulsen SA, McLeish MJ, Grunewald GL, Martin JL. Drinkwater N, et al. Among authors: mcleish mj. Biochem J. 2010 Oct 1;431(1):51-61. doi: 10.1042/BJ20100651. Biochem J. 2010. PMID: 20642456

9

Kinetic and pH studies on human phenylethanolamine N-methyltransferase.

Wu Q, McLeish MJ. Wu Q, et al. Among authors: mcleish mj. Arch Biochem Biophys. 2013 Nov 1;539(1):1-8. doi: 10.1016/j.abb.2013.08.019. Epub 2013 Sep 7. Arch Biochem Biophys. 2013. PMID: 24018397 Free PMC article.

10

Getting the adrenaline going: crystal structure of the adrenaline-synthesizing enzyme PNMT.

Martin JL, Begun J, McLeish MJ, Caine JM, Grunewald GL. Martin JL, et al. Among authors: mcleish mj. Structure. 2001 Oct;9(10):977-85. doi: 10.1016/s0969-2126(01)00662-1. Structure. 2001. PMID: 11591352 Free article.

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