Stürzebecher J - Search Results

1

Effective inhibition of experimental metastasis and prolongation of survival in mice by a potent factor Xa-specific synthetic serine protease inhibitor with weak anticoagulant activity.

Banke IJ, Arlt MJ, Mueller MM, Sperl S, Stemberger A, Stürzebecher J, Amirkhosravi A, Moroder L, Krüger A. Banke IJ, et al. Among authors: sturzebecher j. Thromb Haemost. 2005 Nov;94(5):1084-93. doi: 10.1160/TH05-04-0249. Thromb Haemost. 2005. PMID: 16363253

2

Increase of anti-metastatic efficacy by selectivity- but not affinity-optimization of synthetic serine protease inhibitors.

Banke IJ, Arlt MJ, Pennington C, Kopitz C, Steinmetzer T, Schweinitz A, Gansbacher B, Quigley JP, Edwards DR, Stürzebecher J, Krüger A. Banke IJ, et al. Among authors: sturzebecher j. Biol Chem. 2003 Oct-Nov;384(10-11):1515-25. doi: 10.1515/BC.2003.168. Biol Chem. 2003. PMID: 14669995

3

(R)-3-Amidinophenylalanine-derived inhibitors of factor Xa with a novel active-site binding mode.

Mueller MM, Sperl S, Stürzebecher J, Bode W, Moroder L. Mueller MM, et al. Among authors: sturzebecher j. Biol Chem. 2002 Jul-Aug;383(7-8):1185-91. doi: 10.1515/BC.2002.130. Biol Chem. 2002. PMID: 12437104

4

Urethanyl-3-amidinophenylalanine derivatives as inhibitors of factor Xa. X-ray crystal structure of a trypsin/inhibitor complex and modeling studies.

Sperl S, Bergner A, Stürzebecher J, Magdolen V, Bode W, Moroder L. Sperl S, et al. Among authors: sturzebecher j. Biol Chem. 2000 Apr;381(4):321-9. doi: 10.1515/BC.2000.042. Biol Chem. 2000. PMID: 10839461

5

Inhibition of thrombin generation in plasma by inhibitors of factor Xa.

Prasa D, Svendsen L, Stürzebecher J. Prasa D, et al. Among authors: sturzebecher j. Thromb Haemost. 1997 Oct;78(4):1215-20. Thromb Haemost. 1997. PMID: 9364987

6

Design of novel and selective inhibitors of urokinase-type plasminogen activator with improved pharmacokinetic properties for use as antimetastatic agents.

Schweinitz A, Steinmetzer T, Banke IJ, Arlt MJ, Stürzebecher A, Schuster O, Geissler A, Giersiefen H, Zeslawska E, Jacob U, Krüger A, Stürzebecher J. Schweinitz A, et al. Among authors: sturzebecher j, sturzebecher a. J Biol Chem. 2004 Aug 6;279(32):33613-22. doi: 10.1074/jbc.M314151200. Epub 2004 May 18. J Biol Chem. 2004. PMID: 15150279 Free article.

7

Design of benzamidine-type inhibitors of factor Xa.

Gabriel B, Stubbs MT, Bergner A, Hauptmann J, Bode W, Stürzebecher J, Moroder L. Gabriel B, et al. Among authors: sturzebecher j. J Med Chem. 1998 Oct 22;41(22):4240-50. doi: 10.1021/jm980227t. J Med Chem. 1998. PMID: 9784099

8

(4-aminomethyl)phenylguanidine derivatives as nonpeptidic highly selective inhibitors of human urokinase.

Sperl S, Jacob U, Arroyo de Prada N, Stürzebecher J, Wilhelm OG, Bode W, Magdolen V, Huber R, Moroder L. Sperl S, et al. Among authors: sturzebecher j. Proc Natl Acad Sci U S A. 2000 May 9;97(10):5113-8. doi: 10.1073/pnas.97.10.5113. Proc Natl Acad Sci U S A. 2000. PMID: 10805774 Free PMC article.

9

Comparison of the anticoagulant and antithrombotic effects of synthetic thrombin and factor Xa inhibitors.

Hauptmann J, Kaiser B, Nowak G, Stürzebecher J, Markwardt F. Hauptmann J, et al. Among authors: sturzebecher j. Thromb Haemost. 1990 Apr 12;63(2):220-3. Thromb Haemost. 1990. PMID: 2363124

10

Crystals of the urokinase type plasminogen activator variant beta(c)-uPAin complex with small molecule inhibitors open the way towards structure-based drug design.

Zeslawska E, Schweinitz A, Karcher A, Sondermann P, Sperl S, Stürzebecher J, Jacob U. Zeslawska E, et al. Among authors: sturzebecher j. J Mol Biol. 2000 Aug 11;301(2):465-75. doi: 10.1006/jmbi.2000.3966. J Mol Biol. 2000. PMID: 10926521

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