Sperl S - Search Results

1

Effective inhibition of experimental metastasis and prolongation of survival in mice by a potent factor Xa-specific synthetic serine protease inhibitor with weak anticoagulant activity.

Banke IJ, Arlt MJ, Mueller MM, Sperl S, Stemberger A, Stürzebecher J, Amirkhosravi A, Moroder L, Krüger A. Banke IJ, et al. Among authors: sperl s. Thromb Haemost. 2005 Nov;94(5):1084-93. doi: 10.1160/TH05-04-0249. Thromb Haemost. 2005. PMID: 16363253

2

(R)-3-Amidinophenylalanine-derived inhibitors of factor Xa with a novel active-site binding mode.

Mueller MM, Sperl S, Stürzebecher J, Bode W, Moroder L. Mueller MM, et al. Among authors: sperl s. Biol Chem. 2002 Jul-Aug;383(7-8):1185-91. doi: 10.1515/BC.2002.130. Biol Chem. 2002. PMID: 12437104

3

Urethanyl-3-amidinophenylalanine derivatives as inhibitors of factor Xa. X-ray crystal structure of a trypsin/inhibitor complex and modeling studies.

Sperl S, Bergner A, Stürzebecher J, Magdolen V, Bode W, Moroder L. Sperl S, et al. Biol Chem. 2000 Apr;381(4):321-9. doi: 10.1515/BC.2000.042. Biol Chem. 2000. PMID: 10839461

4

Urokinase-type plasminogen activator (uPA) and its receptor (uPAR): development of antagonists of uPA/uPAR interaction and their effects in vitro and in vivo.

Reuning U, Sperl S, Kopitz C, Kessler H, Krüger A, Schmitt M, Magdolen V. Reuning U, et al. Among authors: sperl s. Curr Pharm Des. 2003;9(19):1529-43. doi: 10.2174/1381612033454612. Curr Pharm Des. 2003. PMID: 12871066 Review.

5

(4-aminomethyl)phenylguanidine derivatives as nonpeptidic highly selective inhibitors of human urokinase.

Sperl S, Jacob U, Arroyo de Prada N, Stürzebecher J, Wilhelm OG, Bode W, Magdolen V, Huber R, Moroder L. Sperl S, et al. Proc Natl Acad Sci U S A. 2000 May 9;97(10):5113-8. doi: 10.1073/pnas.97.10.5113. Proc Natl Acad Sci U S A. 2000. PMID: 10805774 Free PMC article.

6

Inhibition of the tumor-associated urokinase-type plasminogen activation system: effects of high-level synthesis of soluble urokinase receptor in ovarian and breast cancer cells in vitro and in vivo.

Magdolen V, Krüger A, Sato S, Nagel J, Sperl S, Reuning U, Rettenberger P, Magdolen U, Schmitt M. Magdolen V, et al. Among authors: sperl s. Recent Results Cancer Res. 2003;162:43-63. doi: 10.1007/978-3-642-59349-9_4. Recent Results Cancer Res. 2003. PMID: 12790320 Review.

7

The uPA/uPA receptor system as a target for tumor therapy.

Sperl S, Mueller MM, Wilhelm OG, Schmitt M, Magdolen V, Moroder L. Sperl S, et al. Drug News Perspect. 2001 Sep;14(7):401-11. doi: 10.1358/dnp.2001.14.7.858423. Drug News Perspect. 2001. PMID: 12813583

8

Crystals of the urokinase type plasminogen activator variant beta(c)-uPAin complex with small molecule inhibitors open the way towards structure-based drug design.

Zeslawska E, Schweinitz A, Karcher A, Sondermann P, Sperl S, Stürzebecher J, Jacob U. Zeslawska E, et al. Among authors: sperl s. J Mol Biol. 2000 Aug 11;301(2):465-75. doi: 10.1006/jmbi.2000.3966. J Mol Biol. 2000. PMID: 10926521

9

Natural and synthetic inhibitors of the tumor-associated serine protease urokinase-type plasminogen activator.

Magdolen V, Arroyo de Prada N, Sperl S, Muehlenweg B, Luther T, Wilhelm OG, Magdolen U, Graeff H, Reuning U, Schmitt M. Magdolen V, et al. Among authors: sperl s. Adv Exp Med Biol. 2000;477:331-41. doi: 10.1007/0-306-46826-3_36. Adv Exp Med Biol. 2000. PMID: 10849761 Review. No abstract available.

10

Interaction of plasminogen activator inhibitor type-1 (PAI-1) with vitronectin.

Arroyo De Prada N, Schroeck F, Sinner EK, Muehlenweg B, Twellmeyer J, Sperl S, Wilhelm OG, Schmitt M, Magdolen V. Arroyo De Prada N, et al. Among authors: sperl s. Eur J Biochem. 2002 Jan;269(1):184-92. doi: 10.1046/j.0014-2956.2002.02639.x. Eur J Biochem. 2002. PMID: 11784312 Free article.

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