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Endosomal acidification and activation of NADPH oxidase isoforms are upstream events in hyperosmolarity-induced hepatocyte apoptosis.
Reinehr R, Becker S, Braun J, Eberle A, Grether-Beck S, Haüssinger D. Reinehr R, et al. Among authors: becker s. J Biol Chem. 2006 Aug 11;281(32):23150-66. doi: 10.1074/jbc.M601451200. Epub 2006 Jun 13. J Biol Chem. 2006. PMID: 16772302 Free article.
Bafilomycin and DIDS prevented the hyperosmolarity-induced increase in ceramide formation, p47phox phosphorylation, and ROS formation. As shown recently (Reinehr, R., Becker, S., Hongen, A., and Haussinger, D. (2004) J. Biol. Chem. 279, 23977-23987), hyperosmolarity …
Bafilomycin and DIDS prevented the hyperosmolarity-induced increase in ceramide formation, p47phox phosphorylation, and ROS formation. As sh …
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