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Challenges for blood-brain barrier (BBB) screening.
Jeffrey P, Summerfield SG. Jeffrey P, et al. Among authors: summerfield sg. Xenobiotica. 2007 Oct-Nov;37(10-11):1135-51. doi: 10.1080/00498250701570285. Xenobiotica. 2007. PMID: 17968740 Review.
Toward an improved prediction of human in vivo brain penetration.
Summerfield SG, Lucas AJ, Porter RA, Jeffrey P, Gunn RN, Read KR, Stevens AJ, Metcalf AC, Osuna MC, Kilford PJ, Passchier J, Ruffo AD. Summerfield SG, et al. Xenobiotica. 2008 Dec;38(12):1518-35. doi: 10.1080/00498250802499459. Xenobiotica. 2008. PMID: 18979396
The cyclooxygenase-2 inhibitor GW406381X [2-(4-ethoxyphenyl)-3-[4-(methylsulfonyl)phenyl]-pyrazolo[1,5-b]pyridazine] is effective in animal models of neuropathic pain and central sensitization.
Bingham S, Beswick PJ, Bountra C, Brown T, Campbell IB, Chessell IP, Clayton N, Collins SD, Davey PT, Goodland H, Gray N, Haslam C, Hatcher JP, Hunter AJ, Lucas F, Murkitt G, Naylor A, Pickup E, Sargent B, Summerfield SG, Stevens A, Stratton SC, Wiseman J. Bingham S, et al. Among authors: summerfield sg. J Pharmacol Exp Ther. 2005 Mar;312(3):1161-9. doi: 10.1124/jpet.104.075267. Epub 2004 Nov 30. J Pharmacol Exp Ther. 2005. PMID: 15572651
47 results