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Vaccination with the recombinant Brucella outer membrane protein 31 or a derived 27-amino-acid synthetic peptide elicits a CD4+ T helper 1 response that protects against Brucella melitensis infection.
Cassataro J, Estein SM, Pasquevich KA, Velikovsky CA, de la Barrera S, Bowden R, Fossati CA, Giambartolomei GH. Cassataro J, et al. Among authors: pasquevich ka. Infect Immun. 2005 Dec;73(12):8079-88. doi: 10.1128/IAI.73.12.8079-8088.2005. Infect Immun. 2005. PMID: 16299302 Free PMC article.
A DNA vaccine coding for the Brucella outer membrane protein 31 confers protection against B. melitensis and B. ovis infection by eliciting a specific cytotoxic response.
Cassataro J, Velikovsky CA, de la Barrera S, Estein SM, Bruno L, Bowden R, Pasquevich KA, Fossati CA, Giambartolomei GH. Cassataro J, et al. Among authors: pasquevich ka. Infect Immun. 2005 Oct;73(10):6537-46. doi: 10.1128/IAI.73.10.6537-6546.2005. Infect Immun. 2005. PMID: 16177328 Free PMC article.
A recombinant subunit vaccine based on the insertion of 27 amino acids from Omp31 to the N-terminus of BLS induced a similar degree of protection against B. ovis than Rev.1 vaccination.
Cassataro J, Pasquevich KA, Estein SM, Laplagne DA, Velikovsky CA, de la Barrera S, Bowden R, Fossati CA, Giambartolomei GH, Goldbaum FA. Cassataro J, et al. Among authors: pasquevich ka. Vaccine. 2007 May 30;25(22):4437-46. doi: 10.1016/j.vaccine.2007.03.028. Epub 2007 Apr 2. Vaccine. 2007. PMID: 17442465
A DNA vaccine coding for the chimera BLSOmp31 induced a better degree of protection against B. ovis and a similar degree of protection against B. melitensis than Rev.1 vaccination.
Cassataro J, Pasquevich KA, Estein SM, Laplagne DA, Zwerdling A, de la Barrera S, Bowden R, Fossati CA, Giambartolomei GH, Goldbaum FA. Cassataro J, et al. Among authors: pasquevich ka. Vaccine. 2007 Aug 10;25(32):5958-67. doi: 10.1016/j.vaccine.2007.05.049. Epub 2007 Jun 12. Vaccine. 2007. PMID: 17600596
Brucella abortus inhibits major histocompatibility complex class II expression and antigen processing through interleukin-6 secretion via Toll-like receptor 2.
Barrionuevo P, Cassataro J, Delpino MV, Zwerdling A, Pasquevich KA, García Samartino C, Wallach JC, Fossati CA, Giambartolomei GH. Barrionuevo P, et al. Among authors: pasquevich ka. Infect Immun. 2008 Jan;76(1):250-62. doi: 10.1128/IAI.00949-07. Epub 2007 Nov 5. Infect Immun. 2008. PMID: 17984211 Free PMC article.
Brucella lipoproteins mimic dendritic cell maturation induced by Brucella abortus.
Zwerdling A, Delpino MV, Barrionuevo P, Cassataro J, Pasquevich KA, García Samartino C, Fossati CA, Giambartolomei GH. Zwerdling A, et al. Among authors: pasquevich ka. Microbes Infect. 2008 Oct;10(12-13):1346-54. doi: 10.1016/j.micinf.2008.07.035. Epub 2008 Aug 12. Microbes Infect. 2008. PMID: 18761420 Free article.
Immunization with recombinant Brucella species outer membrane protein Omp16 or Omp19 in adjuvant induces specific CD4+ and CD8+ T cells as well as systemic and oral protection against Brucella abortus infection.
Pasquevich KA, Estein SM, García Samartino C, Zwerdling A, Coria LM, Barrionuevo P, Fossati CA, Giambartolomei GH, Cassataro J. Pasquevich KA, et al. Infect Immun. 2009 Jan;77(1):436-45. doi: 10.1128/IAI.01151-08. Epub 2008 Nov 3. Infect Immun. 2009. PMID: 18981242 Free PMC article.
Brucella abortus activates human neutrophils.
Zwerdling A, Delpino MV, Pasquevich KA, Barrionuevo P, Cassataro J, García Samartino C, Giambartolomei GH. Zwerdling A, et al. Among authors: pasquevich ka. Microbes Infect. 2009 May-Jun;11(6-7):689-97. doi: 10.1016/j.micinf.2009.04.010. Epub 2009 Apr 17. Microbes Infect. 2009. PMID: 19376263 Free article.
Brucella abortus induces the secretion of proinflammatory mediators from glial cells leading to astrocyte apoptosis.
García Samartino C, Delpino MV, Pott Godoy C, Di Genaro MS, Pasquevich KA, Zwerdling A, Barrionuevo P, Mathieu P, Cassataro J, Pitossi F, Giambartolomei GH. García Samartino C, et al. Among authors: pasquevich ka. Am J Pathol. 2010 Mar;176(3):1323-38. doi: 10.2353/ajpath.2010.090503. Epub 2010 Jan 21. Am J Pathol. 2010. PMID: 20093491 Free PMC article.
33 results