Rothweiler U - Search Results

1

NMR indicates that the small molecule RITA does not block p53-MDM2 binding in vitro.

Krajewski M, Ozdowy P, D'Silva L, Rothweiler U, Holak TA. Krajewski M, et al. Among authors: rothweiler u. Nat Med. 2005 Nov;11(11):1135-6; author reply 1136-7. doi: 10.1038/nm1105-1135. Nat Med. 2005. PMID: 16270059 No abstract available.

2

Monitoring the effects of antagonists on protein-protein interactions with NMR spectroscopy.

D'Silva L, Ozdowy P, Krajewski M, Rothweiler U, Singh M, Holak TA. D'Silva L, et al. Among authors: rothweiler u. J Am Chem Soc. 2005 Sep 28;127(38):13220-6. doi: 10.1021/ja052143x. J Am Chem Soc. 2005. PMID: 16173750

3

An NMR-based antagonist induced dissociation assay for targeting the ligand-protein and protein-protein interactions in competition binding experiments.

Krajewski M, Rothweiler U, D'Silva L, Majumdar S, Klein C, Holak TA. Krajewski M, et al. Among authors: rothweiler u. J Med Chem. 2007 Sep 6;50(18):4382-7. doi: 10.1021/jm070365v. Epub 2007 Aug 16. J Med Chem. 2007. PMID: 17696513

4

Molecular basis for the inhibition of p53 by Mdmx.

Popowicz GM, Czarna A, Rothweiler U, Szwagierczak A, Krajewski M, Weber L, Holak TA. Popowicz GM, et al. Among authors: rothweiler u. Cell Cycle. 2007 Oct 1;6(19):2386-92. doi: 10.4161/cc.6.19.4740. Epub 2007 Oct 12. Cell Cycle. 2007. PMID: 17938582

5

Isoquinolin-1-one inhibitors of the MDM2-p53 interaction.

Rothweiler U, Czarna A, Krajewski M, Ciombor J, Kalinski C, Khazak V, Ross G, Skobeleva N, Weber L, Holak TA. Rothweiler U, et al. ChemMedChem. 2008 Jul;3(7):1118-28. doi: 10.1002/cmdc.200800025. ChemMedChem. 2008. PMID: 18428185

6

NMR screening for lead compounds using tryptophan-mutated proteins.

Rothweiler U, Czarna A, Weber L, Popowicz GM, Brongel K, Kowalska K, Orth M, Stemmann O, Holak TA. Rothweiler U, et al. J Med Chem. 2008 Aug 28;51(16):5035-42. doi: 10.1021/jm8002813. Epub 2008 Aug 5. J Med Chem. 2008. PMID: 18680271

7

Shugoshin is a Mad1/Cdc20-like interactor of Mad2.

Orth M, Mayer B, Rehm K, Rothweiler U, Heidmann D, Holak TA, Stemmann O. Orth M, et al. Among authors: rothweiler u. EMBO J. 2011 Jun 10;30(14):2868-80. doi: 10.1038/emboj.2011.187. EMBO J. 2011. PMID: 21666598 Free PMC article.

8

DYRK1A Kinase Inhibitors Promote β-Cell Survival and Insulin Homeostasis.

Barzowska A, Pucelik B, Pustelny K, Matsuda A, Martyniak A, Stępniewski J, Maksymiuk A, Dawidowski M, Rothweiler U, Dulak J, Dubin G, Czarna A. Barzowska A, et al. Among authors: rothweiler u. Cells. 2021 Aug 31;10(9):2263. doi: 10.3390/cells10092263. Cells. 2021. PMID: 34571911 Free PMC article.

9

Novel Scaffolds for Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase (DYRK1A) Inhibitors.

Czarna A, Wang J, Zelencova D, Liu Y, Deng X, Choi HG, Zhang T, Zhou W, Chang JW, Kildalsen H, Seternes OM, Gray NS, Engh RA, Rothweiler U. Czarna A, et al. Among authors: rothweiler u. J Med Chem. 2018 Sep 13;61(17):7560-7572. doi: 10.1021/acs.jmedchem.7b01847. Epub 2018 Aug 23. J Med Chem. 2018. PMID: 30095246

10

2.09 Å Resolution structure of E. coli HigBA toxin-antitoxin complex reveals an ordered DNA-binding domain and intrinsic dynamics in antitoxin.

Jadhav PV, Sinha VK, Chugh S, Kotyada C, Bachhav D, Singh R, Rothweiler U, Singh M. Jadhav PV, et al. Among authors: rothweiler u. Biochem J. 2020 Oct 30;477(20):4001-4019. doi: 10.1042/BCJ20200363. Biochem J. 2020. PMID: 33000860

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