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PPAR alpha inhibits vascular smooth muscle cell proliferation underlying intimal hyperplasia by inducing the tumor suppressor p16INK4a.
Gizard F, Amant C, Barbier O, Bellosta S, Robillard R, Percevault F, Sevestre H, Krimpenfort P, Corsini A, Rochette J, Glineur C, Fruchart JC, Torpier G, Staels B. Gizard F, et al. Among authors: krimpenfort p. J Clin Invest. 2005 Nov;115(11):3228-38. doi: 10.1172/JCI22756. J Clin Invest. 2005. PMID: 16239970 Free PMC article.
An inducible mouse model of melanoma expressing a defined tumor antigen.
Huijbers IJ, Krimpenfort P, Chomez P, van der Valk MA, Song JY, Inderberg-Suso EM, Schmitt-Verhulst AM, Berns A, Van den Eynde BJ. Huijbers IJ, et al. Among authors: krimpenfort p. Cancer Res. 2006 Mar 15;66(6):3278-86. doi: 10.1158/0008-5472.CAN-05-3216. Cancer Res. 2006. PMID: 16540681 Free article.
SHP2 is required for growth of KRAS-mutant non-small-cell lung cancer in vivo.
Mainardi S, Mulero-Sánchez A, Prahallad A, Germano G, Bosma A, Krimpenfort P, Lieftink C, Steinberg JD, de Wit N, Gonçalves-Ribeiro S, Nadal E, Bardelli A, Villanueva A, Bernards R. Mainardi S, et al. Among authors: krimpenfort p. Nat Med. 2018 Jul;24(7):961-967. doi: 10.1038/s41591-018-0023-9. Epub 2018 May 28. Nat Med. 2018. PMID: 29808006 Free article.
A conditional mouse model for malignant mesothelioma.
Jongsma J, van Montfort E, Vooijs M, Zevenhoven J, Krimpenfort P, van der Valk M, van de Vijver M, Berns A. Jongsma J, et al. Among authors: krimpenfort p. Cancer Cell. 2008 Mar;13(3):261-71. doi: 10.1016/j.ccr.2008.01.030. Cancer Cell. 2008. PMID: 18328429 Free article.
Insertional mutagenesis in mice deficient for p15Ink4b, p16Ink4a, p21Cip1, and p27Kip1 reveals cancer gene interactions and correlations with tumor phenotypes.
Kool J, Uren AG, Martins CP, Sie D, de Ridder J, Turner G, van Uitert M, Matentzoglu K, Lagcher W, Krimpenfort P, Gadiot J, Pritchard C, Lenz J, Lund AH, Jonkers J, Rogers J, Adams DJ, Wessels L, Berns A, van Lohuizen M. Kool J, et al. Among authors: krimpenfort p. Cancer Res. 2010 Jan 15;70(2):520-31. doi: 10.1158/0008-5472.CAN-09-2736. Epub 2010 Jan 12. Cancer Res. 2010. PMID: 20068150 Free PMC article.
67 results