Deshmukh R - Search Results

1

Heme oxidation in a chimeric protein of the alpha-selective Neisseriae meningitidis heme oxygenase with the distal helix of the delta-selective Pseudomonas aeruginosa.

Deshmukh R, Zeng Y, Furci LM, Huang HW, Morgan BN, Sander S, Alontaga AY, Bunce RA, Moënne-Loccoz P, Rivera M, Wilks A. Deshmukh R, et al. Biochemistry. 2005 Oct 25;44(42):13713-23. doi: 10.1021/bi050810t. Biochemistry. 2005. PMID: 16229461

We have previously shown by NMR that the in-plane conformation of the heme in pa-HO is significantly different from that of nm-HO as a result of distinct interactions of the heme propionates with the protein scaffold [Caignan, G. A., Deshmukh, R., Wilks, A., Zeng, Y …

We have previously shown by NMR that the in-plane conformation of the heme in pa-HO is significantly different from that of nm-HO as a resul …

2

Oxidation of heme to beta- and delta-biliverdin by Pseudomonas aeruginosa heme oxygenase as a consequence of an unusual seating of the heme.

Caignan GA, Deshmukh R, Wilks A, Zeng Y, Huang HW, Moënne-Loccoz P, Bunce RA, Eastman MA, Rivera M. Caignan GA, et al. Among authors: deshmukh r. J Am Chem Soc. 2002 Dec 18;124(50):14879-92. doi: 10.1021/ja0274960. J Am Chem Soc. 2002. PMID: 12475329

3

Mixed regioselectivity in the Arg-177 mutants of Corynebacterium diphtheriae heme oxygenase as a consequence of in-plane heme disorder.

Zeng Y, Deshmukh R, Caignan GA, Bunce RA, Rivera M, Wilks A. Zeng Y, et al. Among authors: deshmukh r. Biochemistry. 2004 May 11;43(18):5222-38. doi: 10.1021/bi035970o. Biochemistry. 2004. PMID: 15122888

4

NMR assignments of cd-HO, a 24 kDa heme oxygenase from Corynebacterium diphtheria.

Hom K, Furci LM, Deshmukh R, Wilks A. Hom K, et al. Among authors: deshmukh r. Biomol NMR Assign. 2007 Jul;1(1):55-6. doi: 10.1007/s12104-007-9014-3. Epub 2007 May 9. Biomol NMR Assign. 2007. PMID: 19636825

5

The hydroxide complex of Pseudomonas aeruginosa heme oxygenase as a model of the low-spin iron(III) hydroperoxide intermediate in heme catabolism: 13C NMR spectroscopic studies suggest the active participation of the heme in macrocycle hydroxylation.

Caignan GA, Deshmukh R, Zeng Y, Wilks A, Bunce RA, Rivera M. Caignan GA, et al. Among authors: deshmukh r. J Am Chem Soc. 2003 Oct 1;125(39):11842-52. doi: 10.1021/ja036147i. J Am Chem Soc. 2003. PMID: 14505406

6

Crystal structures of the NO- and CO-bound heme oxygenase from Neisseriae meningitidis. Implications for O2 activation.

Friedman J, Lad L, Deshmukh R, Li H, Wilks A, Poulos TL. Friedman J, et al. Among authors: deshmukh r. J Biol Chem. 2003 Sep 5;278(36):34654-9. doi: 10.1074/jbc.M302985200. Epub 2003 Jun 22. J Biol Chem. 2003. PMID: 12819228 Free article.

7

Homologues of neisserial heme oxygenase in gram-negative bacteria: degradation of heme by the product of the pigA gene of Pseudomonas aeruginosa.

Ratliff M, Zhu W, Deshmukh R, Wilks A, Stojiljkovic I. Ratliff M, et al. Among authors: deshmukh r. J Bacteriol. 2001 Nov;183(21):6394-403. doi: 10.1128/JB.183.21.6394-6403.2001. J Bacteriol. 2001. PMID: 11591684 Free PMC article.

8

Therapeutic potential of GABA(B) receptor ligands in drug addiction, anxiety, depression and other CNS disorders.

Kumar K, Sharma S, Kumar P, Deshmukh R. Kumar K, et al. Among authors: deshmukh r. Pharmacol Biochem Behav. 2013 Sep;110:174-84. doi: 10.1016/j.pbb.2013.07.003. Epub 2013 Jul 17. Pharmacol Biochem Behav. 2013. PMID: 23872369 Review.

9

SP600125, a competitive inhibitor of JNK attenuates streptozotocin induced neurocognitive deficit and oxidative stress in rats.

Sharma N, Deshmukh R, Bedi KL. Sharma N, et al. Among authors: deshmukh r. Pharmacol Biochem Behav. 2010 Oct;96(4):386-94. doi: 10.1016/j.pbb.2010.06.010. Epub 2010 Jun 30. Pharmacol Biochem Behav. 2010. PMID: 20600246

10

Neuroprotective effect of RO-20-1724-a phosphodiesterase4 inhibitor against intracerebroventricular streptozotocin induced cognitive deficit and oxidative stress in rats.

Sharma V, Bala A, Deshmukh R, Bedi KL, Sharma PL. Sharma V, et al. Among authors: deshmukh r. Pharmacol Biochem Behav. 2012 Apr;101(2):239-45. doi: 10.1016/j.pbb.2012.01.004. Epub 2012 Jan 20. Pharmacol Biochem Behav. 2012. PMID: 22285388

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