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The cytoplasmic domain of Alzheimer's amyloid-beta protein precursor causes sustained apoptosis signal-regulating kinase 1/c-Jun NH2-terminal kinase-mediated neurotoxic signal via dimerization.
Hashimoto Y, Niikura T, Chiba T, Tsukamoto E, Kadowaki H, Nishitoh H, Yamagishi Y, Ishizaka M, Yamada M, Nawa M, Terashita K, Aiso S, Ichijo H, Nishimoto I. Hashimoto Y, et al. Among authors: yamada m. J Pharmacol Exp Ther. 2003 Sep;306(3):889-902. doi: 10.1124/jpet.103.051383. Epub 2003 Jun 26. J Pharmacol Exp Ther. 2003. PMID: 12829723
Two serine residues distinctly regulate the rescue function of Humanin, an inhibiting factor of Alzheimer's disease-related neurotoxicity: functional potentiation by isomerization and dimerization.
Terashita K, Hashimoto Y, Niikura T, Tajima H, Yamagishi Y, Ishizaka M, Kawasumi M, Chiba T, Kanekura K, Yamada M, Nawa M, Kita Y, Aiso S, Nishimoto I. Terashita K, et al. Among authors: yamada m. J Neurochem. 2003 Jun;85(6):1521-38. doi: 10.1046/j.1471-4159.2003.01797.x. J Neurochem. 2003. PMID: 12787071 Free article.
Targeted introduction of V642I mutation in amyloid precursor protein gene causes functional abnormality resembling early stage of Alzheimer's disease in aged mice.
Kawasumi M, Chiba T, Yamada M, Miyamae-Kaneko M, Matsuoka M, Nakahara J, Tomita T, Iwatsubo T, Kato S, Aiso S, Nishimoto I, Kouyama K. Kawasumi M, et al. Among authors: yamada m. Eur J Neurosci. 2004 May;19(10):2826-38. doi: 10.1111/j.0953-816X.2004.03397.x. Eur J Neurosci. 2004. PMID: 15147316
8,938 results