Posner GH - Search Results

1

Enantiomeric 1,2,4-trioxanes display equivalent in vitro antimalarial activity versus Plasmodium falciparum malaria parasites: implications for the molecular mechanism of action of the artemisinins.

O'Neill PM, Rawe SL, Borstnik K, Miller A, Ward SA, Bray PG, Davies J, Oh CH, Posner GH. O'Neill PM, et al. Among authors: posner gh. Chembiochem. 2005 Nov;6(11):2048-54. doi: 10.1002/cbic.200500048. Chembiochem. 2005. PMID: 16222725

2

Antimalarial and antitumor evaluation of novel C-10 non-acetal dimers of 10beta-(2-hydroxyethyl)deoxoartemisinin.

Jeyadevan JP, Bray PG, Chadwick J, Mercer AE, Byrne A, Ward SA, Park BK, Williams DP, Cosstick R, Davies J, Higson AP, Irving E, Posner GH, O'Neill PM. Jeyadevan JP, et al. Among authors: posner gh. J Med Chem. 2004 Feb 26;47(5):1290-8. doi: 10.1021/jm030974c. J Med Chem. 2004. PMID: 14971909

3

Knowledge of the proposed chemical mechanism of action and cytochrome p450 metabolism of antimalarial trioxanes like artemisinin allows rational design of new antimalarial peroxides.

Posner GH, O'Neill PM. Posner GH, et al. Acc Chem Res. 2004 Jun;37(6):397-404. doi: 10.1021/ar020227u. Acc Chem Res. 2004. PMID: 15196049

4

Malaria: new chemotherapeutic peroxide drugs.

Borstnik K, Paik IH, Posner GH. Borstnik K, et al. Among authors: posner gh. Mini Rev Med Chem. 2002 Dec;2(6):573-83. doi: 10.2174/1389557023405620. Mini Rev Med Chem. 2002. PMID: 12370042 Review.

5

Antimalarial chemotherapeutic peroxides: artemisinin, yingzhaosu A and related compounds.

Borstnik K, Paik IH, Shapiro TA, Posner GH. Borstnik K, et al. Among authors: posner gh. Int J Parasitol. 2002 Dec 4;32(13):1661-7. doi: 10.1016/s0020-7519(02)00195-9. Int J Parasitol. 2002. PMID: 12435451 Review.

6

A medicinal chemistry perspective on artemisinin and related endoperoxides.

O'Neill PM, Posner GH. O'Neill PM, et al. Among authors: posner gh. J Med Chem. 2004 Jun 3;47(12):2945-64. doi: 10.1021/jm030571c. J Med Chem. 2004. PMID: 15163175 Review. No abstract available.

7

Synthesis, antimalarial activity, biomimetic iron(II) chemistry, and in vivo metabolism of novel, potent C-10-phenoxy derivatives of dihydroartemisinin.

O'Neill PM, Miller A, Bishop LP, Hindley S, Maggs JL, Ward SA, Roberts SM, Scheinmann F, Stachulski AV, Posner GH, Park BK. O'Neill PM, et al. Among authors: posner gh. J Med Chem. 2001 Jan 4;44(1):58-68. doi: 10.1021/jm000987f. J Med Chem. 2001. PMID: 11141088

8

Orally active, water-soluble antimalarial 3-aryltrioxanes: short synthesis and preclinical efficacy testing in rodents.

Posner GH, Jeon HB, Ploypradith P, Paik IH, Borstnik K, Xie S, Shapiro TA. Posner GH, et al. J Med Chem. 2002 Aug 29;45(18):3824-8. doi: 10.1021/jm020210h. J Med Chem. 2002. PMID: 12190305

9

Orally active, antimalarial, anticancer, artemisinin-derived trioxane dimers with high stability and efficacy.

Posner GH, Paik IH, Sur S, McRiner AJ, Borstnik K, Xie S, Shapiro TA. Posner GH, et al. J Med Chem. 2003 Mar 13;46(6):1060-5. doi: 10.1021/jm020461q. J Med Chem. 2003. PMID: 12620083

10

Anticancer and antimalarial efficacy and safety of artemisinin-derived trioxane dimers in rodents.

Posner GH, McRiner AJ, Paik IH, Sur S, Borstnik K, Xie S, Shapiro TA, Alagbala A, Foster B. Posner GH, et al. J Med Chem. 2004 Feb 26;47(5):1299-301. doi: 10.1021/jm0303711. J Med Chem. 2004. PMID: 14971910

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