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Dual-targeting CRISPR-CasRx reduces C9orf72 ALS/FTD sense and antisense repeat RNAs in vitro and in vivo.
Kempthorne L, Vaizoglu D, Cammack AJ, Carcolé M, Roberts MJ, Mikheenko A, Fisher A, Suklai P, Muralidharan B, Kroll F, Moens TG, Yshii L, Verschoren S, Hölbling BV, Moreira FC, Katona E, Coneys R, de Oliveira P, Zhang YJ, Jansen K, Daughrity LM, McGown A, Ramesh TM, Van Den Bosch L, Lignani G, Rahim AA, Coyne AN, Petrucelli L, Rihel J, Isaacs AM. Kempthorne L, et al. Among authors: fisher a. Nat Commun. 2025 Jan 8;16(1):459. doi: 10.1038/s41467-024-55550-x. Nat Commun. 2025. PMID: 39779704 Free PMC article.
Inosine monophosphate dehydrogenase 2 (IMPDH2) modulates response to therapy and chemo-resistance in triple negative breast cancer.
da Silva Fernandes T, Gillard BM, Dai T, Martin JC, Chaudhry KA, Dugas SM, Fisher AA, Sharma P, Wu R, Attwood KM, Dasgupta S, Takabe K, Rosario SR, Bianchi-Smiraglia A. da Silva Fernandes T, et al. Among authors: fisher aa. Sci Rep. 2025 Jan 7;15(1):1061. doi: 10.1038/s41598-024-85094-5. Sci Rep. 2025. PMID: 39774345 Free PMC article.
4,220 results