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Substitution of the transmembrane domain of Vpu in simian-human immunodeficiency virus (SHIVKU1bMC33) with that of M2 of influenza A results in a virus that is sensitive to inhibitors of the M2 ion channel and is pathogenic for pig-tailed macaques.
Hout DR, Gomez ML, Pacyniak E, Gomez LM, Fegley B, Mulcahy ER, Hill MS, Culley N, Pinson DM, Nothnick W, Powers MF, Wong SW, Stephens EB. Hout DR, et al. Among authors: pacyniak e. Virology. 2006 Jan 20;344(2):541-59. doi: 10.1016/j.virol.2005.08.022. Epub 2005 Sep 30. Virology. 2006. PMID: 16199074 Free article.
Deletion of the vpu sequences prior to the env in a simian-human immunodeficiency virus results in enhanced Env precursor synthesis but is less pathogenic for pig-tailed macaques.
Stephens EB, McCormick C, Pacyniak E, Griffin D, Pinson DM, Sun F, Nothnick W, Wong SW, Gunderson R, Berman NE, Singh DK. Stephens EB, et al. Among authors: pacyniak e. Virology. 2002 Feb 15;293(2):252-61. doi: 10.1006/viro.2001.1244. Virology. 2002. PMID: 11886245 Free article.
The presence of the casein kinase II phosphorylation sites of Vpu enhances the CD4(+) T cell loss caused by the simian-human immunodeficiency virus SHIV(KU-lbMC33) in pig-tailed macaques.
Singh DK, Griffin DM, Pacyniak E, Jackson M, Werle MJ, Wisdom B, Sun F, Hout DR, Pinson DM, Gunderson RS, Powers MF, Wong SW, Stephens EB. Singh DK, et al. Among authors: pacyniak e. Virology. 2003 Sep 1;313(2):435-51. doi: 10.1016/s0042-6822(03)00339-8. Virology. 2003. PMID: 12954211 Free article.
Fusion of the upstream vpu sequences to the env of simian human immunodeficiency virus (SHIV(KU-1bMC33)) results in the synthesis of two envelope precursor proteins, increased numbers of virus particles associated with the cell surface and is pathogenic for pig-tailed macaques.
Hout DR, Gomez ML, Pacyniak E, Mulcahy ER, Gomez LM, Jackson M, Flick M, Fegley B, McCormick C, Wisdom BJ, Culley N, Pinson DM, Powers M, Wong SW, Stephens EB. Hout DR, et al. Among authors: pacyniak e. Virology. 2004 May 20;323(1):91-107. doi: 10.1016/j.virol.2004.02.028. Virology. 2004. PMID: 15165822 Free article.
Identification of a region within the cytoplasmic domain of the subtype B Vpu protein of human immunodeficiency virus type 1 (HIV-1) that is responsible for retention in the golgi complex and its absence in the Vpu protein from a subtype C HIV-1.
Pacyniak E, Gomez ML, Gomez LM, Mulcahy ER, Jackson M, Hout DR, Wisdom BJ, Stephens EB. Pacyniak E, et al. AIDS Res Hum Retroviruses. 2005 May;21(5):379-94. doi: 10.1089/aid.2005.21.379. AIDS Res Hum Retroviruses. 2005. PMID: 15929700
23 results