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Substitution of the transmembrane domain of Vpu in simian-human immunodeficiency virus (SHIVKU1bMC33) with that of M2 of influenza A results in a virus that is sensitive to inhibitors of the M2 ion channel and is pathogenic for pig-tailed macaques.
Hout DR, Gomez ML, Pacyniak E, Gomez LM, Fegley B, Mulcahy ER, Hill MS, Culley N, Pinson DM, Nothnick W, Powers MF, Wong SW, Stephens EB. Hout DR, et al. Among authors: nothnick w. Virology. 2006 Jan 20;344(2):541-59. doi: 10.1016/j.virol.2005.08.022. Epub 2005 Sep 30. Virology. 2006. PMID: 16199074 Free article.
Deletion of the vpu sequences prior to the env in a simian-human immunodeficiency virus results in enhanced Env precursor synthesis but is less pathogenic for pig-tailed macaques.
Stephens EB, McCormick C, Pacyniak E, Griffin D, Pinson DM, Sun F, Nothnick W, Wong SW, Gunderson R, Berman NE, Singh DK. Stephens EB, et al. Among authors: nothnick w. Virology. 2002 Feb 15;293(2):252-61. doi: 10.1006/viro.2001.1244. Virology. 2002. PMID: 11886245 Free article.
Loss of the repressor REST in uterine fibroids promotes aberrant G protein-coupled receptor 10 expression and activates mammalian target of rapamycin pathway.
Varghese BV, Koohestani F, McWilliams M, Colvin A, Gunewardena S, Kinsey WH, Nowak RA, Nothnick WB, Chennathukuzhi VM. Varghese BV, et al. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):2187-92. doi: 10.1073/pnas.1215759110. Epub 2013 Jan 2. Proc Natl Acad Sci U S A. 2013. PMID: 23284171 Free PMC article.
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