Rubin LL - Search Results

1

Modulation of hair growth with small molecule agonists of the hedgehog signaling pathway.

Paladini RD, Saleh J, Qian C, Xu GX, Rubin LL. Paladini RD, et al. Among authors: rubin ll. J Invest Dermatol. 2005 Oct;125(4):638-46. doi: 10.1111/j.0022-202X.2005.23867.x. J Invest Dermatol. 2005. PMID: 16185261 Free article.

2

Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists.

Frank-Kamenetsky M, Zhang XM, Bottega S, Guicherit O, Wichterle H, Dudek H, Bumcrot D, Wang FY, Jones S, Shulok J, Rubin LL, Porter JA. Frank-Kamenetsky M, et al. Among authors: rubin ll. J Biol. 2002 Nov 6;1(2):10. doi: 10.1186/1475-4924-1-10. J Biol. 2002. PMID: 12437772 Free PMC article.

3

Identification of a small molecule inhibitor of the hedgehog signaling pathway: effects on basal cell carcinoma-like lesions.

Williams JA, Guicherit OM, Zaharian BI, Xu Y, Chai L, Wichterle H, Kon C, Gatchalian C, Porter JA, Rubin LL, Wang FY. Williams JA, et al. Among authors: rubin ll. Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4616-21. doi: 10.1073/pnas.0732813100. Epub 2003 Apr 4. Proc Natl Acad Sci U S A. 2003. PMID: 12679522 Free PMC article.

4

The hedgehog pathway and neurological disorders.

Dellovade T, Romer JT, Curran T, Rubin LL. Dellovade T, et al. Among authors: rubin ll. Annu Rev Neurosci. 2006;29:539-63. doi: 10.1146/annurev.neuro.29.051605.112858. Annu Rev Neurosci. 2006. PMID: 16776596 Review.

5

Targeting the Hedgehog pathway in cancer.

Rubin LL, de Sauvage FJ. Rubin LL, et al. Nat Rev Drug Discov. 2006 Dec;5(12):1026-33. doi: 10.1038/nrd2086. Nat Rev Drug Discov. 2006. PMID: 17139287 Review.

6

GDC-0449-a potent inhibitor of the hedgehog pathway.

Robarge KD, Brunton SA, Castanedo GM, Cui Y, Dina MS, Goldsmith R, Gould SE, Guichert O, Gunzner JL, Halladay J, Jia W, Khojasteh C, Koehler MF, Kotkow K, La H, Lalonde RL, Lau K, Lee L, Marshall D, Marsters JC Jr, Murray LJ, Qian C, Rubin LL, Salphati L, Stanley MS, Stibbard JH, Sutherlin DP, Ubhayaker S, Wang S, Wong S, Xie M. Robarge KD, et al. Among authors: rubin ll. Bioorg Med Chem Lett. 2009 Oct 1;19(19):5576-81. doi: 10.1016/j.bmcl.2009.08.049. Epub 2009 Aug 15. Bioorg Med Chem Lett. 2009. PMID: 19716296

7

Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1(+/-)p53(-/-) mice.

Romer JT, Kimura H, Magdaleno S, Sasai K, Fuller C, Baines H, Connelly M, Stewart CF, Gould S, Rubin LL, Curran T. Romer JT, et al. Among authors: rubin ll. Cancer Cell. 2004 Sep;6(3):229-40. doi: 10.1016/j.ccr.2004.08.019. Cancer Cell. 2004. PMID: 15380514 Free article.

8

Potent inhibitors of the hedgehog signaling pathway.

Brunton SA, Stibbard JH, Rubin LL, Kruse LI, Guicherit OM, Boyd EA, Price S. Brunton SA, et al. Among authors: rubin ll. J Med Chem. 2008 Mar 13;51(5):1108-10. doi: 10.1021/jm070694n. Epub 2008 Feb 15. J Med Chem. 2008. PMID: 18275133

9

A small molecule that directs differentiation of human ESCs into the pancreatic lineage.

Chen S, Borowiak M, Fox JL, Maehr R, Osafune K, Davidow L, Lam K, Peng LF, Schreiber SL, Rubin LL, Melton D. Chen S, et al. Among authors: rubin ll. Nat Chem Biol. 2009 Apr;5(4):258-65. doi: 10.1038/nchembio.154. Epub 2009 Mar 15. Nat Chem Biol. 2009. PMID: 19287398

10

Sonic hedgehog is required for progenitor cell maintenance in telencephalic stem cell niches.

Machold R, Hayashi S, Rutlin M, Muzumdar MD, Nery S, Corbin JG, Gritli-Linde A, Dellovade T, Porter JA, Rubin LL, Dudek H, McMahon AP, Fishell G. Machold R, et al. Among authors: rubin ll. Neuron. 2003 Sep 11;39(6):937-50. doi: 10.1016/s0896-6273(03)00561-0. Neuron. 2003. PMID: 12971894 Free article.

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