Hirono S - Search Results

1

Hydrolysis of angiotensin II receptor blocker prodrug olmesartan medoxomil by human serum albumin and identification of its catalytic active sites.

Ma SF, Anraku M, Iwao Y, Yamasaki K, Kragh-Hansen U, Yamaotsu N, Hirono S, Ikeda T, Otagiri M. Ma SF, et al. Among authors: hirono s. Drug Metab Dispos. 2005 Dec;33(12):1911-9. doi: 10.1124/dmd.105.006163. Epub 2005 Sep 23. Drug Metab Dispos. 2005. PMID: 16183779

2

Esterase-like activity of serum albumin: characterization of its structural chemistry using p-nitrophenyl esters as substrates.

Sakurai Y, Ma SF, Watanabe H, Yamaotsu N, Hirono S, Kurono Y, Kragh-Hansen U, Otagiri M. Sakurai Y, et al. Among authors: hirono s. Pharm Res. 2004 Feb;21(2):285-92. doi: 10.1023/b:pham.0000016241.84630.06. Pharm Res. 2004. PMID: 15032310

3

Differential effects of methoxy group on the interaction of curcuminoids with two major ligand binding sites of human serum albumin.

Sato H, Chuang VT, Yamasaki K, Yamaotsu N, Watanabe H, Nagumo K, Anraku M, Kadowaki D, Ishima Y, Hirono S, Otagiri M, Maruyama T. Sato H, et al. Among authors: hirono s. PLoS One. 2014 Feb 3;9(2):e87919. doi: 10.1371/journal.pone.0087919. eCollection 2014. PLoS One. 2014. PMID: 24498401 Free PMC article.

4

Long chain fatty acids alter the interactive binding of ligands to the two principal drug binding sites of human serum albumin.

Yamasaki K, Hyodo S, Taguchi K, Nishi K, Yamaotsu N, Hirono S, Chuang VTG, Seo H, Maruyama T, Otagiri M. Yamasaki K, et al. Among authors: hirono s. PLoS One. 2017 Jun 29;12(6):e0180404. doi: 10.1371/journal.pone.0180404. eCollection 2017. PLoS One. 2017. PMID: 28662200 Free PMC article.

5

Use of photoaffinity labeling and site-directed mutagenesis for identification of the key residue responsible for extraordinarily high affinity binding of UCN-01 in human alpha1-acid glycoprotein.

Katsuki M, Chuang VT, Nishi K, Kawahara K, Nakayama H, Yamaotsu N, Hirono S, Otagiri M. Katsuki M, et al. Among authors: hirono s. J Biol Chem. 2005 Jan 14;280(2):1384-91. doi: 10.1074/jbc.M411076200. Epub 2004 Oct 27. J Biol Chem. 2005. PMID: 15509559 Free article.

6

Gibbs Free Energy of Hydrolytic Water Molecule in Acyl-Enzyme Intermediates of a Serine Protease: A Potential Application for Computer-Aided Discovery of Mechanism-Based Reversible Covalent Inhibitors.

Masuda Y, Yamaotsu N, Hirono S. Masuda Y, et al. Among authors: hirono s. Chem Pharm Bull (Tokyo). 2017;65(10):889-892. doi: 10.1248/cpb.c17-00425. Chem Pharm Bull (Tokyo). 2017. PMID: 28966272 Free article.

7

Determination of ligand-binding sites on proteins using long-range hydrophobic potential.

Yamaotsu N, Oda A, Hirono S. Yamaotsu N, et al. Among authors: hirono s. Biol Pharm Bull. 2008 Aug;31(8):1552-8. doi: 10.1248/bpb.31.1552. Biol Pharm Bull. 2008. PMID: 18670088 Free article.

8

Analysis of affinities of penicillins for a class C beta-lactamase by molecular dynamics simulations.

Tsuchida K, Yamaotsu N, Hirono S. Tsuchida K, et al. Among authors: hirono s. Drug Des Discov. 1999 Aug;16(2):145-53. Drug Des Discov. 1999. PMID: 10533810

9

Linear Discriminant Analysis for the in Silico Discovery of Mechanism-Based Reversible Covalent Inhibitors of a Serine Protease: Application of Hydration Thermodynamics Analysis and Semi-empirical Molecular Orbital Calculation.

Masuda Y, Yoshida T, Yamaotsu N, Hirono S. Masuda Y, et al. Among authors: hirono s. Chem Pharm Bull (Tokyo). 2018;66(4):399-409. doi: 10.1248/cpb.c17-00854. Chem Pharm Bull (Tokyo). 2018. PMID: 29607905 Free article.

10

In silico multi-filter screening approaches for developing novel beta-secretase inhibitors.

Fujimoto T, Matsushita Y, Gouda H, Yamaotsu N, Hirono S. Fujimoto T, et al. Among authors: hirono s. Bioorg Med Chem Lett. 2008 May 1;18(9):2771-5. doi: 10.1016/j.bmcl.2008.04.011. Epub 2008 Apr 10. Bioorg Med Chem Lett. 2008. PMID: 18434150

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