Ceramide 1-phosphate is required for the translocation of group IVA cytosolic phospholipase A2 and prostaglandin synthesis.
Lamour NF, Subramanian P, Wijesinghe DS, Stahelin RV, Bonventre JV, Chalfant CE.
Lamour NF, et al. Among authors: subramanian p.
J Biol Chem. 2009 Sep 25;284(39):26897-907. doi: 10.1074/jbc.M109.001677. Epub 2009 Jul 23.
J Biol Chem. 2009.
PMID: 19632995
Free PMC article.
In opposition to this accepted mechanism of two decades, ceramide 1-phosphate (C1P) has been shown to increase the membrane association of cPLA(2)alpha in vitro via a novel site in the cationic beta-groove of the C2 domain (Stahelin, R. V., Subramanian, P., Vora, M. …
In opposition to this accepted mechanism of two decades, ceramide 1-phosphate (C1P) has been shown to increase the membrane association of c …