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Page 1
Substituted sulfonamide bioisosteres of 8-hydroxyquinoline as zinc-dependent antibacterial compounds.
McGowan JE, Harper AD, Davison EK, Jeong JY, Mros S, Harbison-Price N, Van Zuylen EM, Knottenbelt MK, Heikal A, Ferguson SA, McConnell MA, Cook GM, Krittaphol W, Walker GF, Brimble MA, Rennison D. McGowan JE, et al. Among authors: cook gm. Bioorg Med Chem Lett. 2020 Jun 1;30(11):127110. doi: 10.1016/j.bmcl.2020.127110. Epub 2020 Mar 16. Bioorg Med Chem Lett. 2020. PMID: 32229060
Antitubercular polyhalogenated phenothiazines and phenoselenazine with reduced binding to CNS receptors.
Nizi MG, Desantis J, Nakatani Y, Massari S, Mazzarella MA, Shetye G, Sabatini S, Barreca ML, Manfroni G, Felicetti T, Rushton-Green R, Hards K, Latacz G, Satała G, Bojarski AJ, Cecchetti V, Kolář MH, Handzlik J, Cook GM, Franzblau SG, Tabarrini O. Nizi MG, et al. Among authors: cook gm. Eur J Med Chem. 2020 Sep 1;201:112420. doi: 10.1016/j.ejmech.2020.112420. Epub 2020 Jun 5. Eur J Med Chem. 2020. PMID: 32526553
C-2 derivatized 8-sulfonamidoquinolines as antibacterial compounds.
Davison EK, McGowan JE, Li FF, Harper AD, Jeong JY, Mros S, Harbison-Price N, Van Zuylen EM, Knottenbelt MK, Heikal A, Ferguson SA, McConnell MA, Cook GM, Krittaphol W, Walker GF, Brimble MA, Rennison D. Davison EK, et al. Among authors: cook gm. Bioorg Med Chem. 2021 Jan 1;29:115837. doi: 10.1016/j.bmc.2020.115837. Epub 2020 Nov 6. Bioorg Med Chem. 2021. PMID: 33223463
Systematic evaluation of structure-property relationships and pharmacokinetics in 6-(hetero)aryl-substituted matched pair analogs of amiloride and 5-(N,N-hexamethylene)amiloride.
Buckley BJ, Aboelela A, Majed H, Bujaroski RS, White KL, Powell AK, Wang W, Katneni K, Saunders J, Shackleford DM, Charman SA, Cook GM, Kelso MJ, Ranson M. Buckley BJ, et al. Among authors: cook gm. Bioorg Med Chem. 2021 May 1;37:116116. doi: 10.1016/j.bmc.2021.116116. Epub 2021 Mar 23. Bioorg Med Chem. 2021. PMID: 33799173
341 results