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A Rac1/phosphatidylinositol 3-kinase/Akt3 anti-apoptotic pathway, triggered by AlsinLF, the product of the ALS2 gene, antagonizes Cu/Zn-superoxide dismutase (SOD1) mutant-induced motoneuronal cell death.
Kanekura K, Hashimoto Y, Kita Y, Sasabe J, Aiso S, Nishimoto I, Matsuoka M. Kanekura K, et al. Among authors: sasabe j. J Biol Chem. 2005 Feb 11;280(6):4532-43. doi: 10.1074/jbc.M410508200. Epub 2004 Dec 3. J Biol Chem. 2005. PMID: 15579468 Free article.
Development of a femtomolar-acting humanin derivative named colivelin by attaching activity-dependent neurotrophic factor to its N terminus: characterization of colivelin-mediated neuroprotection against Alzheimer's disease-relevant insults in vitro and in vivo.
Chiba T, Yamada M, Hashimoto Y, Sato M, Sasabe J, Kita Y, Terashita K, Aiso S, Nishimoto I, Matsuoka M. Chiba T, et al. Among authors: sasabe j. J Neurosci. 2005 Nov 2;25(44):10252-61. doi: 10.1523/JNEUROSCI.3348-05.2005. J Neurosci. 2005. PMID: 16267233 Free PMC article.
Colivelin prolongs survival of an ALS model mouse.
Chiba T, Yamada M, Sasabe J, Terashita K, Aiso S, Matsuoka M, Nishimoto I. Chiba T, et al. Among authors: sasabe j. Biochem Biophys Res Commun. 2006 May 12;343(3):793-8. doi: 10.1016/j.bbrc.2006.02.184. Epub 2006 Mar 10. Biochem Biophys Res Commun. 2006. PMID: 16564029
D-Ser-containing humanin shows promotion of fibril formation.
Hayashi K, Sasabe J, Chiba T, Aiso S, Utsunomiya-Tate N. Hayashi K, et al. Among authors: sasabe j. Amino Acids. 2012 Jun;42(6):2293-7. doi: 10.1007/s00726-011-0971-6. Epub 2011 Jul 7. Amino Acids. 2012. PMID: 21735222
42 results