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Development of a femtomolar-acting humanin derivative named colivelin by attaching activity-dependent neurotrophic factor to its N terminus: characterization of colivelin-mediated neuroprotection against Alzheimer's disease-relevant insults in vitro and in vivo.
Chiba T, Yamada M, Hashimoto Y, Sato M, Sasabe J, Kita Y, Terashita K, Aiso S, Nishimoto I, Matsuoka M. Chiba T, et al. Among authors: nishimoto i. J Neurosci. 2005 Nov 2;25(44):10252-61. doi: 10.1523/JNEUROSCI.3348-05.2005. J Neurosci. 2005. PMID: 16267233 Free PMC article.
Unravelling the role of Humanin.
Nishimoto I, Matsuoka M, niikura T. Nishimoto I, et al. Trends Mol Med. 2004 Mar;10(3):102-5. doi: 10.1016/j.molmed.2004.01.001. Trends Mol Med. 2004. PMID: 15106598 Review.
Humanin antagonists: mutants that interfere with dimerization inhibit neuroprotection by Humanin.
Hashimoto Y, Terashita K, Niikura T, Yamagishi Y, Ishizaka M, Kanekura K, Chiba T, Yamada M, Kita Y, Aiso S, Matsuoka M, Nishimoto I. Hashimoto Y, et al. Among authors: nishimoto i. Eur J Neurosci. 2004 May;19(9):2356-64. doi: 10.1111/j.0953-816X.2004.03298.x. Eur J Neurosci. 2004. PMID: 15128389
We have previously shown that P3A, S7A, C8A, L9A, L12A, T13A, S14A and P19A mutations nullify the neuroprotective function of HN [Yamagishi, Y., Hashimoto, Y., Niikura, T. & Nishimoto, I. (2003) Peptides, 24, 585-595]. Here we examined whether any of these 'null …
We have previously shown that P3A, S7A, C8A, L9A, L12A, T13A, S14A and P19A mutations nullify the neuroprotective function of HN [Yamagishi, …
Targeted introduction of V642I mutation in amyloid precursor protein gene causes functional abnormality resembling early stage of Alzheimer's disease in aged mice.
Kawasumi M, Chiba T, Yamada M, Miyamae-Kaneko M, Matsuoka M, Nakahara J, Tomita T, Iwatsubo T, Kato S, Aiso S, Nishimoto I, Kouyama K. Kawasumi M, et al. Among authors: nishimoto i. Eur J Neurosci. 2004 May;19(10):2826-38. doi: 10.1111/j.0953-816X.2004.03397.x. Eur J Neurosci. 2004. PMID: 15147316
209 results