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Further structural exploration of trisubstituted asymmetric pyran derivatives (2S,4R,5R)-2-benzhydryl-5-benzylamino-tetrahydropyran-4-ol and their corresponding disubstituted (3S,6S) pyran derivatives: a proposed pharmacophore model for high-affinity interaction with the dopamine, serotonin, and norepinephrine transporters.
Zhang S, Fernandez F, Hazeldine S, Deschamps J, Zhen J, Reith ME, Dutta AK. Zhang S, et al. Among authors: zhen j. J Med Chem. 2006 Jul 13;49(14):4239-47. doi: 10.1021/jm0601699. J Med Chem. 2006. PMID: 16821783
Further structure-activity relationships study of hybrid 7-{[2-(4-phenylpiperazin-1-yl)ethyl]propylamino}-5,6,7,8-tetrahydronaphthalen-2-ol analogues: identification of a high-affinity D3-preferring agonist with potent in vivo activity with long duration of action.
Biswas S, Zhang S, Fernandez F, Ghosh B, Zhen J, Kuzhikandathil E, Reith ME, Dutta AK. Biswas S, et al. Among authors: zhen j. J Med Chem. 2008 Jan 10;51(1):101-17. doi: 10.1021/jm070860r. Epub 2007 Dec 12. J Med Chem. 2008. PMID: 18072730
Further structural optimization of cis-(6-benzhydryl-piperidin-3-yl)-benzylamine and 1,4-diazabicyclo[3.3.1]nonane derivatives by introducing an exocyclic hydroxyl group: interaction with dopamine, serotonin, and norepinephrine transporters.
Mishra M, Kolhatkar R, Zhen J, Parrington I, Reith ME, Dutta AK. Mishra M, et al. Among authors: zhen j. Bioorg Med Chem. 2008 Mar 15;16(6):2769-78. doi: 10.1016/j.bmc.2008.01.009. Epub 2008 Jan 11. Bioorg Med Chem. 2008. PMID: 18249549 Free PMC article.
Further structure-activity relationship studies on 4-((((3S,6S)-6-benzhydryltetrahydro-2H-pyran-3-yl)amino)methyl)phenol: identification of compounds with triple uptake inhibitory activity as potential antidepressant agents.
Gopishetty B, Hazeldine S, Santra S, Johnson M, Modi G, Ali S, Zhen J, Reith M, Dutta A. Gopishetty B, et al. Among authors: zhen j. J Med Chem. 2011 Apr 28;54(8):2924-32. doi: 10.1021/jm200020a. Epub 2011 Mar 29. J Med Chem. 2011. PMID: 21446715 Free PMC article.
817 results