Bristow LJ - Search Results

1

Benzazoles as allosteric potentiators of metabotropic glutamate receptor 2 (mGluR2): efficacy in an animal model for schizophrenia.

Govek SP, Bonnefous C, Hutchinson JH, Kamenecka T, McQuiston J, Pracitto R, Zhao LX, Gardner MF, James JK, Daggett LP, Rowe BA, Schaffhauser H, Bristow LJ, Campbell UC, Rodriguez DE, Vernier JM. Govek SP, et al. Among authors: bristow lj. Bioorg Med Chem Lett. 2005 Sep 15;15(18):4068-72. doi: 10.1016/j.bmcl.2005.06.017. Bioorg Med Chem Lett. 2005. PMID: 16005222

2

Pharmacological characterization and identification of amino acids involved in the positive modulation of metabotropic glutamate receptor subtype 2.

Schaffhauser H, Rowe BA, Morales S, Chavez-Noriega LE, Yin R, Jachec C, Rao SP, Bain G, Pinkerton AB, Vernier JM, Bristow LJ, Varney MA, Daggett LP. Schaffhauser H, et al. Among authors: bristow lj. Mol Pharmacol. 2003 Oct;64(4):798-810. doi: 10.1124/mol.64.4.798. Mol Pharmacol. 2003. PMID: 14500736

3

Phenyl-tetrazolyl acetophenones: discovery of positive allosteric potentiatiors for the metabotropic glutamate 2 receptor.

Pinkerton AB, Vernier JM, Schaffhauser H, Rowe BA, Campbell UC, Rodriguez DE, Lorrain DS, Baccei CS, Daggett LP, Bristow LJ. Pinkerton AB, et al. Among authors: bristow lj. J Med Chem. 2004 Aug 26;47(18):4595-9. doi: 10.1021/jm040088h. J Med Chem. 2004. PMID: 15317469

4

Metabotropic glutamate subtype 5 receptors modulate locomotor activity and sensorimotor gating in rodents.

Kinney GG, Burno M, Campbell UC, Hernandez LM, Rodriguez D, Bristow LJ, Conn PJ. Kinney GG, et al. Among authors: bristow lj. J Pharmacol Exp Ther. 2003 Jul;306(1):116-23. doi: 10.1124/jpet.103.048702. Epub 2003 Mar 26. J Pharmacol Exp Ther. 2003. PMID: 12660307

5

Group II mGlu receptor activation suppresses norepinephrine release in the ventral hippocampus and locomotor responses to acute ketamine challenge.

Lorrain DS, Schaffhauser H, Campbell UC, Baccei CS, Correa LD, Rowe B, Rodriguez DE, Anderson JJ, Varney MA, Pinkerton AB, Vernier JM, Bristow LJ. Lorrain DS, et al. Among authors: bristow lj. Neuropsychopharmacology. 2003 Sep;28(9):1622-32. doi: 10.1038/sj.npp.1300238. Epub 2003 Jun 25. Neuropsychopharmacology. 2003. PMID: 12825094

6

The mGluR5 antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) potentiates PCP-induced cognitive deficits in rats.

Campbell UC, Lalwani K, Hernandez L, Kinney GG, Conn PJ, Bristow LJ. Campbell UC, et al. Among authors: bristow lj. Psychopharmacology (Berl). 2004 Sep;175(3):310-8. doi: 10.1007/s00213-004-1827-5. Psychopharmacology (Berl). 2004. PMID: 15024550

7

Distribution of metabotropic glutamate 2 and 3 receptors in the rat forebrain: Implication in emotional responses and central disinhibition.

Gu G, Lorrain DS, Wei H, Cole RL, Zhang X, Daggett LP, Schaffhauser HJ, Bristow LJ, Lechner SM. Gu G, et al. Among authors: bristow lj. Brain Res. 2008 Mar 4;1197:47-62. doi: 10.1016/j.brainres.2007.12.057. Epub 2008 Jan 3. Brain Res. 2008. PMID: 18242587

8

3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]-pyridine: a potent and highly selective metabotropic glutamate subtype 5 receptor antagonist with anxiolytic activity.

Cosford ND, Tehrani L, Roppe J, Schweiger E, Smith ND, Anderson J, Bristow L, Brodkin J, Jiang X, McDonald I, Rao S, Washburn M, Varney MA. Cosford ND, et al. J Med Chem. 2003 Jan 16;46(2):204-6. doi: 10.1021/jm025570j. J Med Chem. 2003. PMID: 12519057

9

Triazolopyridine ethers as potent, orally active mGlu₂ positive allosteric modulators for treating schizophrenia.

Higgins MA, Marcin LR, Christopher Zusi F, Gentles R, Ding M, Pearce BC, Easton A, Kostich WA, Seager MA, Bourin C, Bristow LJ, Johnson KA, Miller R, Hogan J, Whiterock V, Gulianello M, Ferrante M, Huang Y, Hendricson A, Alt A, Macor JE, Bronson JJ. Higgins MA, et al. Among authors: bristow lj. Bioorg Med Chem. 2017 Jan 15;25(2):496-513. doi: 10.1016/j.bmc.2016.11.018. Epub 2016 Nov 14. Bioorg Med Chem. 2017. PMID: 27914948

10

Effects of ketamine and N-methyl-D-aspartate on glutamate and dopamine release in the rat prefrontal cortex: modulation by a group II selective metabotropic glutamate receptor agonist LY379268.

Lorrain DS, Baccei CS, Bristow LJ, Anderson JJ, Varney MA. Lorrain DS, et al. Among authors: bristow lj. Neuroscience. 2003;117(3):697-706. doi: 10.1016/s0306-4522(02)00652-8. Neuroscience. 2003. PMID: 12617973

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