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Page 1
Functional analysis of four naturally occurring variants of human constitutive androstane receptor.
Ikeda S, Kurose K, Jinno H, Sai K, Ozawa S, Hasegawa R, Komamura K, Kotake T, Morishita H, Kamakura S, Kitakaze M, Tomoike H, Tamura T, Yamamoto N, Kunitoh H, Yamada Y, Ohe Y, Shimada Y, Shirao K, Kubota K, Minami H, Ohtsu A, Yoshida T, Saijo N, Saito Y, Sawada J. Ikeda S, et al. Among authors: hasegawa r. Mol Genet Metab. 2005 Sep-Oct;86(1-2):314-9. doi: 10.1016/j.ymgme.2005.05.011. Epub 2005 Jun 28. Mol Genet Metab. 2005. PMID: 15990349
Functional characterization of four naturally occurring variants of human pregnane X receptor (PXR): one variant causes dramatic loss of both DNA binding activity and the transactivation of the CYP3A4 promoter/enhancer region.
Koyano S, Kurose K, Saito Y, Ozawa S, Hasegawa R, Komamura K, Ueno K, Kamakura S, Kitakaze M, Nakajima T, Matsumoto K, Akasawa A, Saito H, Sawada J. Koyano S, et al. Among authors: hasegawa r. Drug Metab Dispos. 2004 Jan;32(1):149-54. doi: 10.1124/dmd.32.1.149. Drug Metab Dispos. 2004. PMID: 14709632
Haplotype analysis of ABCB1/MDR1 blocks in a Japanese population reveals genotype-dependent renal clearance of irinotecan.
Sai K, Kaniwa N, Itoda M, Saito Y, Hasegawa R, Komamura K, Ueno K, Kamakura S, Kitakaze M, Shirao K, Minami H, Ohtsu A, Yoshida T, Saijo N, Kitamura Y, Kamatani N, Ozawa S, Sawada J. Sai K, et al. Among authors: hasegawa r. Pharmacogenetics. 2003 Dec;13(12):741-57. doi: 10.1097/00008571-200312000-00005. Pharmacogenetics. 2003. PMID: 14646693
UGT1A1 haplotypes associated with reduced glucuronidation and increased serum bilirubin in irinotecan-administered Japanese patients with cancer.
Sai K, Saeki M, Saito Y, Ozawa S, Katori N, Jinno H, Hasegawa R, Kaniwa N, Sawada J, Komamura K, Ueno K, Kamakura S, Kitakaze M, Kitamura Y, Kamatani N, Minami H, Ohtsu A, Shirao K, Yoshida T, Saijo N. Sai K, et al. Among authors: hasegawa r. Clin Pharmacol Ther. 2004 Jun;75(6):501-15. doi: 10.1016/j.clpt.2004.01.010. Clin Pharmacol Ther. 2004. PMID: 15179405
Eleven novel single nucleotide polymorphisms in the NR1I2 (PXR) gene, four of which induce non-synonymous amino acid alterations.
Koyano S, Kurose K, Ozawa S, Saeki M, Nakajima Y, Hasegawa R, Komamura K, Ueno K, Kamakura S, Nakajima T, Saito H, Kimura H, Goto Y, Saitoh O, Katoh M, Ohnuma T, Kawai M, Sugai K, Ohtsuki T, Suzuki C, Minami N, Saito Y, Sawada J. Koyano S, et al. Among authors: hasegawa r. Drug Metab Pharmacokinet. 2002;17(6):561-5. doi: 10.2133/dmpk.17.561. Drug Metab Pharmacokinet. 2002. PMID: 15618712 Free article.
Twenty-six novel single nucleotide polymorphisms and their frequencies of the NR1I3 (CAR) gene in a Japanese population.
Ikeda S, Kurose K, Ozawa S, Sai K, Hasegawa R, Komamura K, Ueno K, Kamakura S, Kitakaze M, Tomoike H, Nakajima T, Matsumoto K, Saito H, Goto Y, Kimura H, Katoh M, Sugai K, Minami N, Shirao K, Tamura T, Yamamoto N, Minami H, Ohtsu A, Yoshida T, Saijo N, Saito Y, Sawada J. Ikeda S, et al. Among authors: hasegawa r. Drug Metab Pharmacokinet. 2003;18(6):413-8. doi: 10.2133/dmpk.18.413. Drug Metab Pharmacokinet. 2003. PMID: 15618763 Free article. No abstract available.
Genetic variations and haplotypes of CYP2C19 in a Japanese population.
Fukushima-Uesaka H, Saito Y, Maekawa K, Ozawa S, Hasegawa R, Kajio H, Kuzuya N, Yasuda K, Kawamoto M, Kamatani N, Suzuki K, Yanagawa T, Tohkin M, Sawada J. Fukushima-Uesaka H, et al. Among authors: hasegawa r. Drug Metab Pharmacokinet. 2005 Aug;20(4):300-7. doi: 10.2133/dmpk.20.300. Drug Metab Pharmacokinet. 2005. PMID: 16141610 Free article.
632 results