Buynak JD - Search Results

1

Clavulanic acid inactivation of SHV-1 and the inhibitor-resistant S130G SHV-1 beta-lactamase. Insights into the mechanism of inhibition.

Sulton D, Pagan-Rodriguez D, Zhou X, Liu Y, Hujer AM, Bethel CR, Helfand MS, Thomson JM, Anderson VE, Buynak JD, Ng LM, Bonomo RA. Sulton D, et al. Among authors: buynak jd. J Biol Chem. 2005 Oct 21;280(42):35528-36. doi: 10.1074/jbc.M501251200. Epub 2005 Jun 29. J Biol Chem. 2005. PMID: 15987690 Free article.

2

Cephalosporin-derived inhibitors of beta-lactamase. Part 4: The C3 substituent.

Buynak JD, Vogeti L, Doppalapudi VR, Solomon GM, Chen H. Buynak JD, et al. Bioorg Med Chem Lett. 2002 Jun 17;12(12):1663-6. doi: 10.1016/s0960-894x(02)00205-6. Bioorg Med Chem Lett. 2002. PMID: 12039585

3

The discovery and development of modified penicillin- and cephalosporin-derived beta-lactamase inhibitors.

Buynak JD. Buynak JD. Curr Med Chem. 2004 Jul;11(14):1951-64. doi: 10.2174/0929867043364847. Curr Med Chem. 2004. PMID: 15279575 Review.

4

Structure-activity relationships of different beta-lactam antibiotics against a soluble form of Enterococcus faecium PBP5, a type II bacterial transpeptidase.

Hujer AM, Kania M, Gerken T, Anderson VE, Buynak JD, Ge X, Caspers P, Page MG, Rice LB, Bonomo RA. Hujer AM, et al. Among authors: buynak jd. Antimicrob Agents Chemother. 2005 Feb;49(2):612-8. doi: 10.1128/AAC.49.2.612-618.2005. Antimicrob Agents Chemother. 2005. PMID: 15673741 Free PMC article.

5

Synthesis and evaluation of 3-(carboxymethylidene)- and 3-(carboxymethyl)penicillinates as inhibitors of beta-lactamase.

Buynak JD, Ghadachanda VR, Vogeti L, Zhang H, Chen H. Buynak JD, et al. J Org Chem. 2005 May 27;70(11):4510-3. doi: 10.1021/jo050004s. J Org Chem. 2005. PMID: 15903334

6

Understanding the longevity of the beta-lactam antibiotics and of antibiotic/beta-lactamase inhibitor combinations.

Buynak JD. Buynak JD. Biochem Pharmacol. 2006 Mar 30;71(7):930-40. doi: 10.1016/j.bcp.2005.11.012. Epub 2005 Dec 13. Biochem Pharmacol. 2006. PMID: 16359643 Review.

7

Rational design of a beta-lactamase inhibitor achieved via stabilization of the trans-enamine intermediate: 1.28 A crystal structure of wt SHV-1 complex with a penam sulfone.

Padayatti PS, Sheri A, Totir MA, Helfand MS, Carey MP, Anderson VE, Carey PR, Bethel CR, Bonomo RA, Buynak JD, van den Akker F. Padayatti PS, et al. Among authors: buynak jd. J Am Chem Soc. 2006 Oct 11;128(40):13235-42. doi: 10.1021/ja063715w. J Am Chem Soc. 2006. PMID: 17017804 Free PMC article.

8

Efficient inhibition of class A and class D beta-lactamases by Michaelis complexes.

Kalp M, Sheri A, Buynak JD, Bethel CR, Bonomo RA, Carey PR. Kalp M, et al. Among authors: buynak jd. J Biol Chem. 2007 Jul 27;282(30):21588-91. doi: 10.1074/jbc.C700080200. Epub 2007 Jun 8. J Biol Chem. 2007. PMID: 17561511 Free article.

9

Raman crystallographic studies of the intermediates formed by Ser130Gly SHV, a beta-lactamase that confers resistance to clinical inhibitors.

Helfand MS, Taracila MA, Totir MA, Bonomo RA, Buynak JD, van den Akker F, Carey PR. Helfand MS, et al. Among authors: buynak jd. Biochemistry. 2007 Jul 24;46(29):8689-99. doi: 10.1021/bi700581q. Epub 2007 Jun 27. Biochemistry. 2007. PMID: 17595114

10

Sulbactam forms only minimal amounts of irreversible acrylate-enzyme with SHV-1 beta-lactamase.

Totir MA, Helfand MS, Carey MP, Sheri A, Buynak JD, Bonomo RA, Carey PR. Totir MA, et al. Among authors: buynak jd. Biochemistry. 2007 Aug 7;46(31):8980-7. doi: 10.1021/bi7006146. Epub 2007 Jul 13. Biochemistry. 2007. PMID: 17630699 Free PMC article.

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