Kimbell R - Search Results

1

Kinetic characteristics of ICI D1694: a quinazoline antifolate which inhibits thymidylate synthase.

Ward WH, Kimbell R, Jackman AL. Ward WH, et al. Among authors: kimbell r. Biochem Pharmacol. 1992 May 8;43(9):2029-31. doi: 10.1016/0006-2952(92)90646-z. Biochem Pharmacol. 1992. PMID: 1596289

2

Quinazoline antifolate thymidylate synthase inhibitors: replacement of glutamic acid in the C2-methyl series.

Marsham PR, Jackman AL, Barker AJ, Boyle FT, Pegg SJ, Wardleworth JM, Kimbell R, O'Connor BM, Calvert AH, Hughes LR. Marsham PR, et al. Among authors: kimbell r. J Med Chem. 1995 Mar 17;38(6):994-1004. doi: 10.1021/jm00006a019. J Med Chem. 1995. PMID: 7699716

3

Design and synthesis of potent non-polyglutamatable quinazoline antifolate thymidylate synthase inhibitors.

Marsham PR, Wardleworth JM, Boyle FT, Hennequin LF, Kimbell R, Brown M, Jackman AL. Marsham PR, et al. Among authors: kimbell r. J Med Chem. 1999 Sep 23;42(19):3809-20. doi: 10.1021/jm9803727. J Med Chem. 1999. PMID: 10508430

4

A rationale for the clinical development of the thymidylate synthase inhibitor ZD9331 in ovarian and other solid tumours.

Jackman AL, Melin CJ, Kimbell R, Brunton L, Aherne GW, Theti DS, Walton M. Jackman AL, et al. Among authors: kimbell r. Biochim Biophys Acta. 2002 Jul 18;1587(2-3):215-23. doi: 10.1016/s0925-4439(02)00084-4. Biochim Biophys Acta. 2002. PMID: 12084463 Free article. Review.

5

Thymidylate synthase inhibitors: the in vitro activity of a series of heterocyclic benzoyl ring modified 2-desamino-2-methyl-N10-substituted-5,8-dideazafolates.

Jackman AL, Marsham PR, Moran RG, Kimbell R, O'Connor BM, Hughes LR, Calvert AH. Jackman AL, et al. Among authors: kimbell r. Adv Enzyme Regul. 1991;31:13-27. doi: 10.1016/0065-2571(91)90006-8. Adv Enzyme Regul. 1991. PMID: 1877386 Review.

6

ICI D1694, a quinazoline antifolate thymidylate synthase inhibitor that is a potent inhibitor of L1210 tumor cell growth in vitro and in vivo: a new agent for clinical study.

Jackman AL, Taylor GA, Gibson W, Kimbell R, Brown M, Calvert AH, Judson IR, Hughes LR. Jackman AL, et al. Among authors: kimbell r. Cancer Res. 1991 Oct 15;51(20):5579-86. Cancer Res. 1991. PMID: 1913676

7

Quinazoline thymidylate synthase inhibitors: methods for assessing the contribution of polyglutamation to their in vitro activity.

Jackman AL, Kimbell R, Brown M, Brunton L, Boyle FT. Jackman AL, et al. Among authors: kimbell r. Anticancer Drug Des. 1995 Oct;10(7):555-72. Anticancer Drug Des. 1995. PMID: 7495479

8

Quinazoline-based thymidylate synthase inhibitors: relationship between structural modifications and polyglutamation.

Jackman AL, Kimbell R, Brown M, Brunton L, Bisset GM, Bavetsias V, Marsham P, Hughes LR, Boyle FT. Jackman AL, et al. Among authors: kimbell r. Anticancer Drug Des. 1995 Oct;10(7):573-89. Anticancer Drug Des. 1995. PMID: 7495480

9

The role of the reduced-folate carrier and metabolism to intracellular polyglutamates for the activity of ICI D1694.

Jackman AL, Gibson W, Brown M, Kimbell R, Boyle FT. Jackman AL, et al. Among authors: kimbell r. Adv Exp Med Biol. 1993;339:265-76. doi: 10.1007/978-1-4615-2488-5_26. Adv Exp Med Biol. 1993. PMID: 7513935 Review.

10

Mechanisms of acquired resistance to the quinazoline thymidylate synthase inhibitor ZD1694 (Tomudex) in one mouse and three human cell lines.

Jackman AL, Kelland LR, Kimbell R, Brown M, Gibson W, Aherne GW, Hardcastle A, Boyle FT. Jackman AL, et al. Among authors: kimbell r. Br J Cancer. 1995 May;71(5):914-24. doi: 10.1038/bjc.1995.178. Br J Cancer. 1995. PMID: 7537518 Free PMC article.

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