Friedlos F - Search Results

1

Systemic gene-directed enzyme prodrug therapy of hepatocellular carcinoma using a targeted adenovirus armed with carboxypeptidase G2.

Schepelmann S, Hallenbeck P, Ogilvie LM, Hedley D, Friedlos F, Martin J, Scanlon I, Hay C, Hawkins LK, Marais R, Springer CJ. Schepelmann S, et al. Among authors: friedlos f. Cancer Res. 2005 Jun 15;65(12):5003-8. doi: 10.1158/0008-5472.CAN-05-0393. Cancer Res. 2005. PMID: 15958540

2

Three new prodrugs for suicide gene therapy using carboxypeptidase G2 elicit bystander efficacy in two xenograft models.

Friedlos F, Davies L, Scanlon I, Ogilvie LM, Martin J, Stribbling SM, Spooner RA, Niculescu-Duvaz I, Marais R, Springer CJ. Friedlos F, et al. Cancer Res. 2002 Mar 15;62(6):1724-9. Cancer Res. 2002. PMID: 11912146

3

Self-immolative nitrogen mustards prodrugs cleavable by carboxypeptidase G2 (CPG2) showing large cytotoxicity differentials in GDEPT.

Niculescu-Duvaz D, Niculescu-Duvaz I, Friedlos F, Martin J, Lehouritis P, Marais R, Springer CJ. Niculescu-Duvaz D, et al. Among authors: friedlos f. J Med Chem. 2003 Apr 24;46(9):1690-705. doi: 10.1021/jm020462i. J Med Chem. 2003. PMID: 12699387

4

Methods to improve efficacy in suicide gene therapy approaches: targeting prodrug-activating enzymes carboxypeptidase G2 and nitroreductase to different subcellular compartments.

Schepelmann S, Spooner R, Friedlos F, Marais R. Schepelmann S, et al. Among authors: friedlos f. Methods Mol Med. 2004;90:279-301. doi: 10.1385/1-59259-429-8:279. Methods Mol Med. 2004. PMID: 14657569 No abstract available.

5

Novel fluorinated prodrugs for activation by carboxypeptidase G2 showing good in vivo antitumor activity in gene-directed enzyme prodrug therapy.

Davies LC, Friedlos F, Hedley D, Martin J, Ogilvie LM, Scanlon IJ, Springer CJ. Davies LC, et al. Among authors: friedlos f. J Med Chem. 2005 Aug 11;48(16):5321-8. doi: 10.1021/jm0502182. J Med Chem. 2005. PMID: 16078849

6

Activated B-RAF is an Hsp90 client protein that is targeted by the anticancer drug 17-allylamino-17-demethoxygeldanamycin.

da Rocha Dias S, Friedlos F, Light Y, Springer C, Workman P, Marais R. da Rocha Dias S, et al. Among authors: friedlos f. Cancer Res. 2005 Dec 1;65(23):10686-91. doi: 10.1158/0008-5472.CAN-05-2632. Cancer Res. 2005. PMID: 16322212

7

Suicide gene therapy of human colon carcinoma xenografts using an armed oncolytic adenovirus expressing carboxypeptidase G2.

Schepelmann S, Ogilvie LM, Hedley D, Friedlos F, Martin J, Scanlon I, Chen P, Marais R, Springer CJ. Schepelmann S, et al. Among authors: friedlos f. Cancer Res. 2007 May 15;67(10):4949-55. doi: 10.1158/0008-5472.CAN-07-0297. Cancer Res. 2007. PMID: 17510425 Free article.

8

Attenuated Salmonella targets prodrug activating enzyme carboxypeptidase G2 to mouse melanoma and human breast and colon carcinomas for effective suicide gene therapy.

Friedlos F, Lehouritis P, Ogilvie L, Hedley D, Davies L, Bermudes D, King I, Martin J, Marais R, Springer CJ. Friedlos F, et al. Clin Cancer Res. 2008 Jul 1;14(13):4259-66. doi: 10.1158/1078-0432.CCR-07-4800. Clin Cancer Res. 2008. PMID: 18594008

9

Regressions of established breast carcinoma xenografts by carboxypeptidase G2 suicide gene therapy and the prodrug CMDA are due to a bystander effect.

Stribbling SM, Friedlos F, Martin J, Davies L, Spooner RA, Marais R, Springer CJ. Stribbling SM, et al. Among authors: friedlos f. Hum Gene Ther. 2000 Jan 20;11(2):285-92. doi: 10.1089/10430340050016021. Hum Gene Ther. 2000. PMID: 10680842

10

Prodrugs for antibody- and gene-directed enzyme prodrug therapies (ADEPT and GDEPT).

Niculescu-Duvaz I, Friedlos F, Niculescu-Duvaz D, Davies L, Springer CJ. Niculescu-Duvaz I, et al. Among authors: friedlos f. Anticancer Drug Des. 1999 Dec;14(6):517-38. Anticancer Drug Des. 1999. PMID: 10834273 Review.

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