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The oncogenic activity of RET point mutants for follicular thyroid cells may account for the occurrence of papillary thyroid carcinoma in patients affected by familial medullary thyroid carcinoma.
Melillo RM, Cirafici AM, De Falco V, Bellantoni M, Chiappetta G, Fusco A, Carlomagno F, Picascia A, Tramontano D, Tallini G, Santoro M. Melillo RM, et al. Among authors: de falco v. Am J Pathol. 2004 Aug;165(2):511-21. doi: 10.1016/S0002-9440(10)63316-0. Am J Pathol. 2004. PMID: 15277225 Free PMC article.
A new germline RET mutation apparently devoid of transforming activity serendipitously discovered in a patient with atrophic autoimmune thyroiditis and primary ovarian failure.
Orgiana G, Pinna G, Camedda A, De Falco V, Santoro M, Melillo RM, Elisei R, Romei C, Lai S, Carcassi C, Mariotti S. Orgiana G, et al. Among authors: de falco v. J Clin Endocrinol Metab. 2004 Oct;89(10):4810-6. doi: 10.1210/jc.2004-0365. J Clin Endocrinol Metab. 2004. PMID: 15472167
The RET/PTC-RAS-BRAF linear signaling cascade mediates the motile and mitogenic phenotype of thyroid cancer cells.
Melillo RM, Castellone MD, Guarino V, De Falco V, Cirafici AM, Salvatore G, Caiazzo F, Basolo F, Giannini R, Kruhoffer M, Orntoft T, Fusco A, Santoro M. Melillo RM, et al. Among authors: de falco v. J Clin Invest. 2005 Apr;115(4):1068-81. doi: 10.1172/JCI22758. Epub 2005 Mar 10. J Clin Invest. 2005. Retraction in: J Clin Invest. 2016 Apr 1;126(4):1603. doi: 10.1172/JCI87345 PMID: 15761501 Free PMC article. Retracted.
BRAF is a therapeutic target in aggressive thyroid carcinoma.
Salvatore G, De Falco V, Salerno P, Nappi TC, Pepe S, Troncone G, Carlomagno F, Melillo RM, Wilhelm SM, Santoro M. Salvatore G, et al. Among authors: de falco v. Clin Cancer Res. 2006 Mar 1;12(5):1623-9. doi: 10.1158/1078-0432.CCR-05-2378. Clin Cancer Res. 2006. PMID: 16533790 Free article.
93 results