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The RET/PTC-RAS-BRAF linear signaling cascade mediates the motile and mitogenic phenotype of thyroid cancer cells.
Melillo RM, Castellone MD, Guarino V, De Falco V, Cirafici AM, Salvatore G, Caiazzo F, Basolo F, Giannini R, Kruhoffer M, Orntoft T, Fusco A, Santoro M. Melillo RM, et al. Among authors: cirafici am. J Clin Invest. 2005 Apr;115(4):1068-81. doi: 10.1172/JCI22758. Epub 2005 Mar 10. J Clin Invest. 2005. Retraction in: J Clin Invest. 2016 Apr 1;126(4):1603. doi: 10.1172/JCI87345 PMID: 15761501 Free PMC article. Retracted.
The oncogenic activity of RET point mutants for follicular thyroid cells may account for the occurrence of papillary thyroid carcinoma in patients affected by familial medullary thyroid carcinoma.
Melillo RM, Cirafici AM, De Falco V, Bellantoni M, Chiappetta G, Fusco A, Carlomagno F, Picascia A, Tramontano D, Tallini G, Santoro M. Melillo RM, et al. Among authors: cirafici am. Am J Pathol. 2004 Aug;165(2):511-21. doi: 10.1016/S0002-9440(10)63316-0. Am J Pathol. 2004. PMID: 15277225 Free PMC article.
Ret-mediated mitogenesis requires Src kinase activity.
Melillo RM, Barone MV, Lupoli G, Cirafici AM, Carlomagno F, Visconti R, Matoskova B, Di Fiore PP, Vecchio G, Fusco A, Santoro M. Melillo RM, et al. Among authors: cirafici am. Cancer Res. 1999 Mar 1;59(5):1120-6. Cancer Res. 1999. PMID: 10070972
30 results