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Safety pharmacology--a progressive approach.
Redfern WS, Wakefield ID, Prior H, Pollard CE, Hammond TG, Valentin JP. Redfern WS, et al. Fundam Clin Pharmacol. 2002 Jun;16(3):161-73. doi: 10.1046/j.1472-8206.2002.00098.x. Fundam Clin Pharmacol. 2002. PMID: 12165064
The application of in vitro methods to safety pharmacology.
Wakefield ID, Pollard C, Redfern WS, Hammond TG, Valentin JP. Wakefield ID, et al. Among authors: redfern ws. Fundam Clin Pharmacol. 2002 Jun;16(3):209-18. doi: 10.1046/j.1472-8206.2002.00099.x. Fundam Clin Pharmacol. 2002. PMID: 12165068 Review.
Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development.
Redfern WS, Carlsson L, Davis AS, Lynch WG, MacKenzie I, Palethorpe S, Siegl PK, Strang I, Sullivan AT, Wallis R, Camm AJ, Hammond TG. Redfern WS, et al. Cardiovasc Res. 2003 Apr 1;58(1):32-45. doi: 10.1016/s0008-6363(02)00846-5. Cardiovasc Res. 2003. PMID: 12667944 Review.
Validation of the use of zebrafish larvae in visual safety assessment.
Richards FM, Alderton WK, Kimber GM, Liu Z, Strang I, Redfern WS, Valentin JP, Winter MJ, Hutchinson TH. Richards FM, et al. Among authors: redfern ws. J Pharmacol Toxicol Methods. 2008 Jul-Aug;58(1):50-8. doi: 10.1016/j.vascn.2008.04.002. Epub 2008 May 2. J Pharmacol Toxicol Methods. 2008. PMID: 18541443
Approaches to seizure risk assessment in preclinical drug discovery.
Easter A, Bell ME, Damewood JR Jr, Redfern WS, Valentin JP, Winter MJ, Fonck C, Bialecki RA. Easter A, et al. Among authors: redfern ws. Drug Discov Today. 2009 Sep;14(17-18):876-84. doi: 10.1016/j.drudis.2009.06.003. Epub 2009 Jun 21. Drug Discov Today. 2009. PMID: 19545644 Review.
A framework to assess the translation of safety pharmacology data to humans.
Valentin JP, Bialecki R, Ewart L, Hammond T, Leishmann D, Lindgren S, Martinez V, Pollard C, Redfern W, Wallis R. Valentin JP, et al. J Pharmacol Toxicol Methods. 2009 Sep-Oct;60(2):152-8. doi: 10.1016/j.vascn.2009.05.011. Epub 2009 Jul 17. J Pharmacol Toxicol Methods. 2009. PMID: 19616110
47 results