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Bcl-2 homodimerization involves two distinct binding surfaces, a topographic arrangement that provides an effective mechanism for Bcl-2 to capture activated Bax.
Zhang Z, Lapolla SM, Annis MG, Truscott M, Roberts GJ, Miao Y, Shao Y, Tan C, Peng J, Johnson AE, Zhang XC, Andrews DW, Lin J. Zhang Z, et al. Among authors: miao y. J Biol Chem. 2004 Oct 15;279(42):43920-8. doi: 10.1074/jbc.M406412200. Epub 2004 Aug 9. J Biol Chem. 2004. PMID: 15302859 Free PMC article.
Bax forms an oligomer via separate, yet interdependent, surfaces.
Zhang Z, Zhu W, Lapolla SM, Miao Y, Shao Y, Falcone M, Boreham D, McFarlane N, Ding J, Johnson AE, Zhang XC, Andrews DW, Lin J. Zhang Z, et al. Among authors: miao y. J Biol Chem. 2010 Jun 4;285(23):17614-27. doi: 10.1074/jbc.M110.113456. Epub 2010 Apr 9. J Biol Chem. 2010. PMID: 20382739 Free PMC article.
5,488 results