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104 results

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Page 1
Cathepsin S inhibitors as novel immunomodulators.
Thurmond RL, Sun S, Karlsson L, Edwards JP. Thurmond RL, et al. Curr Opin Investig Drugs. 2005 May;6(5):473-82. Curr Opin Investig Drugs. 2005. PMID: 15912960 Review.
Identification of a potent and selective noncovalent cathepsin S inhibitor.
Thurmond RL, Sun S, Sehon CA, Baker SM, Cai H, Gu Y, Jiang W, Riley JP, Williams KN, Edwards JP, Karlsson L. Thurmond RL, et al. J Pharmacol Exp Ther. 2004 Jan;308(1):268-76. doi: 10.1124/jpet.103.056879. Epub 2003 Oct 17. J Pharmacol Exp Ther. 2004. PMID: 14566006
Histamine H4 receptor antagonists: the new antihistamines?
Fung-Leung WP, Thurmond RL, Ling P, Karlsson L. Fung-Leung WP, et al. Among authors: thurmond rl. Curr Opin Investig Drugs. 2004 Nov;5(11):1174-83. Curr Opin Investig Drugs. 2004. PMID: 15573868 Review.
The SAR of 4-substituted (6,6-bicyclic) piperidine cathepsin S inhibitors.
Grice CA, Tays K, Khatuya H, Gustin DJ, Butler CR, Wei J, Sehon CA, Sun S, Gu Y, Jiang W, Thurmond RL, Karlsson L, Edwards JP. Grice CA, et al. Among authors: thurmond rl. Bioorg Med Chem Lett. 2006 Apr 15;16(8):2209-12. doi: 10.1016/j.bmcl.2006.01.038. Epub 2006 Feb 3. Bioorg Med Chem Lett. 2006. PMID: 16458510
Pyrazole-based cathepsin S inhibitors with improved cellular potency.
Wei J, Pio BA, Cai H, Meduna SP, Sun S, Gu Y, Jiang W, Thurmond RL, Karlsson L, Edwards JP. Wei J, et al. Among authors: thurmond rl. Bioorg Med Chem Lett. 2007 Oct 15;17(20):5525-8. doi: 10.1016/j.bmcl.2007.08.038. Epub 2007 Aug 22. Bioorg Med Chem Lett. 2007. PMID: 17822900
Pyrazole-based cathepsin S inhibitors with arylalkynes as P1 binding elements.
Ameriks MK, Axe FU, Bembenek SD, Edwards JP, Gu Y, Karlsson L, Randal M, Sun S, Thurmond RL, Zhu J. Ameriks MK, et al. Among authors: thurmond rl. Bioorg Med Chem Lett. 2009 Nov 1;19(21):6131-4. doi: 10.1016/j.bmcl.2009.09.014. Epub 2009 Sep 10. Bioorg Med Chem Lett. 2009. PMID: 19773165
Discovery and SAR of novel pyrazole-based thioethers as cathepsin S inhibitors: part 1.
Lee-Dutra A, Wiener DK, Arienti KL, Liu J, Mani N, Ameriks MK, Axe FU, Gebauer D, Desai PJ, Nguyen S, Randal M, Thurmond RL, Sun S, Karlsson L, Edwards JP, Jones TK, Grice CA. Lee-Dutra A, et al. Among authors: thurmond rl. Bioorg Med Chem Lett. 2010 Apr 1;20(7):2370-4. doi: 10.1016/j.bmcl.2010.01.108. Epub 2010 Jan 28. Bioorg Med Chem Lett. 2010. PMID: 20153648
104 results