Testa SM - Search Results

1

5' transcript replacement in vitro catalyzed by a group I intron-derived ribozyme.

Alexander RC, Baum DA, Testa SM. Alexander RC, et al. Among authors: testa sm. Biochemistry. 2005 May 31;44(21):7796-804. doi: 10.1021/bi047284a. Biochemistry. 2005. PMID: 15909994

2

Molecular recognition properties of IGS-mediated reactions catalyzed by a Pneumocystis carinii group I intron.

Johnson AK, Baum DA, Tye J, Bell MA, Testa SM. Johnson AK, et al. Among authors: testa sm. Nucleic Acids Res. 2003 Apr 1;31(7):1921-34. doi: 10.1093/nar/gkg280. Nucleic Acids Res. 2003. PMID: 12655009 Free PMC article.

3

Molecular recognition in a trans excision-splicing ribozyme: non-Watson-Crick base pairs at the 5' splice site and omegaG at the 3' splice site can play a role in determining the binding register of reaction substrates.

Baum DA, Sinha J, Testa SM. Baum DA, et al. Among authors: testa sm. Biochemistry. 2005 Jan 25;44(3):1067-77. doi: 10.1021/bi0482304. Biochemistry. 2005. PMID: 15654763

4

In vivo excision of a single targeted nucleotide from an mRNA by a trans excision-splicing ribozyme.

Baum DA, Testa SM. Baum DA, et al. Among authors: testa sm. RNA. 2005 Jun;11(6):897-905. doi: 10.1261/rna.2050505. Epub 2005 May 4. RNA. 2005. PMID: 15872183 Free PMC article.

5

Ribozyme-catalyzed excision of targeted sequences from within RNAs.

Bell MA, Johnson AK, Testa SM. Bell MA, et al. Among authors: testa sm. Biochemistry. 2002 Dec 24;41(51):15327-33. doi: 10.1021/bi0267386. Biochemistry. 2002. PMID: 12484771

6

Trans insertion-splicing: ribozyme-catalyzed insertion of targeted sequences into RNAs.

Johnson AK, Sinha J, Testa SM. Johnson AK, et al. Among authors: testa sm. Biochemistry. 2005 Aug 9;44(31):10702-10. doi: 10.1021/bi0504815. Biochemistry. 2005. PMID: 16060679

7

A Pneumocystis carinii group I intron-derived ribozyme utilizes an endogenous guanosine as the first reaction step nucleophile in the trans excision-splicing reaction.

Dotson PP 2nd, Sinha J, Testa SM. Dotson PP 2nd, et al. Among authors: testa sm. Biochemistry. 2008 Apr 22;47(16):4780-7. doi: 10.1021/bi7020525. Epub 2008 Mar 26. Biochemistry. 2008. PMID: 18363339

8

Canonical nucleosides can be utilized by T4 DNA ligase as universal template bases at ligation junctions.

Alexander RC, Johnson AK, Thorpe JA, Gevedon T, Testa SM. Alexander RC, et al. Among authors: testa sm. Nucleic Acids Res. 2003 Jun 15;31(12):3208-16. doi: 10.1093/nar/gkg415. Nucleic Acids Res. 2003. PMID: 12799448 Free PMC article.

9

Enhancing the second step of the trans excision-splicing reaction of a group I ribozyme by exploiting P9.0 and P10 for intermolecular recognition.

Bell MA, Sinha J, Johnson AK, Testa SM. Bell MA, et al. Among authors: testa sm. Biochemistry. 2004 Apr 13;43(14):4323-31. doi: 10.1021/bi035874n. Biochemistry. 2004. PMID: 15065876

10

A Pneumocystis carinii group I intron ribozyme that does not require 2' OH groups on its 5' exon mimic for binding to the catalytic core.

Testa SM, Haidaris CG, Gigliotti F, Turner DH. Testa SM, et al. Biochemistry. 1997 Dec 9;36(49):15303-14. doi: 10.1021/bi9713097. Biochemistry. 1997. PMID: 9398259

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