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The DYRK1A gene, encoded in chromosome 21 Down syndrome critical region, bridges between beta-amyloid production and tau phosphorylation in Alzheimer disease.
Kimura R, Kamino K, Yamamoto M, Nuripa A, Kida T, Kazui H, Hashimoto R, Tanaka T, Kudo T, Yamagata H, Tabara Y, Miki T, Akatsu H, Kosaka K, Funakoshi E, Nishitomi K, Sakaguchi G, Kato A, Hattori H, Uema T, Takeda M. Kimura R, et al. Among authors: kudo t. Hum Mol Genet. 2007 Jan 1;16(1):15-23. doi: 10.1093/hmg/ddl437. Epub 2006 Nov 29. Hum Mol Genet. 2007. PMID: 17135279
Enzymatic characteristics of I213T mutant presenilin-1/gamma-secretase in cell models and knock-in mouse brains: familial Alzheimer disease-linked mutation impairs gamma-site cleavage of amyloid precursor protein C-terminal fragment beta.
Shimojo M, Sahara N, Mizoroki T, Funamoto S, Morishima-Kawashima M, Kudo T, Takeda M, Ihara Y, Ichinose H, Takashima A. Shimojo M, et al. Among authors: kudo t. J Biol Chem. 2008 Jun 13;283(24):16488-96. doi: 10.1074/jbc.M801279200. Epub 2008 Apr 21. J Biol Chem. 2008. PMID: 18430735 Free article.
Novel therapeutic strategies for neurodegenerative disease.
Tanimukai H, Kudo T, Tanaka T, Grundke-Iqbal I, Iqbal K, Takeda M. Tanimukai H, et al. Among authors: kudo t. Psychogeriatrics. 2009 Jun;9(2):103-9. doi: 10.1111/j.1479-8301.2009.00289.x. Psychogeriatrics. 2009. PMID: 19604333 Free PMC article. Review.
FAD-linked presenilin-1 mutants impede translation regulation under ER stress.
Yasuda Y, Kudo T, Katayama T, Imaizumi K, Yatera M, Okochi M, Yamamori H, Matsumoto N, Kida T, Fukumori A, Okumura M, Tohyama M, Takeda M. Yasuda Y, et al. Among authors: kudo t. Biochem Biophys Res Commun. 2002 Aug 16;296(2):313-8. doi: 10.1016/s0006-291x(02)00859-8. Biochem Biophys Res Commun. 2002. PMID: 12163019
2,877 results