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Page 1
Reverse fosmidomycin derivatives against the antimalarial drug target IspC (Dxr).
Behrendt CT, Kunfermann A, Illarionova V, Matheeussen A, Pein MK, Gräwert T, Kaiser J, Bacher A, Eisenreich W, Illarionov B, Fischer M, Maes L, Groll M, Kurz T. Behrendt CT, et al. Among authors: kurz t. J Med Chem. 2011 Oct 13;54(19):6796-802. doi: 10.1021/jm200694q. Epub 2011 Sep 13. J Med Chem. 2011. PMID: 21866890
IspC as target for antiinfective drug discovery: synthesis, enantiomeric separation, and structural biology of fosmidomycin thia isosters.
Kunfermann A, Lienau C, Illarionov B, Held J, Gräwert T, Behrendt CT, Werner P, Hähn S, Eisenreich W, Riederer U, Mordmüller B, Bacher A, Fischer M, Groll M, Kurz T. Kunfermann A, et al. Among authors: kurz t. J Med Chem. 2013 Oct 24;56(20):8151-62. doi: 10.1021/jm4012559. Epub 2013 Oct 7. J Med Chem. 2013. PMID: 24032981
Binding modes of reverse fosmidomycin analogs toward the antimalarial target IspC.
Konzuch S, Umeda T, Held J, Hähn S, Brücher K, Lienau C, Behrendt CT, Gräwert T, Bacher A, Illarionov B, Fischer M, Mordmüller B, Tanaka N, Kurz T. Konzuch S, et al. Among authors: kurz t. J Med Chem. 2014 Nov 13;57(21):8827-38. doi: 10.1021/jm500850y. Epub 2014 Oct 20. J Med Chem. 2014. PMID: 25254502
Prodrugs of reverse fosmidomycin analogues.
Brücher K, Gräwert T, Konzuch S, Held J, Lienau C, Behrendt C, Illarionov B, Maes L, Bacher A, Wittlin S, Mordmüller B, Fischer M, Kurz T. Brücher K, et al. Among authors: kurz t. J Med Chem. 2015 Feb 26;58(4):2025-35. doi: 10.1021/jm5019719. Epub 2015 Feb 12. J Med Chem. 2015. PMID: 25633870
Discovery of the First-in-Class Dual Histone Deacetylase-Proteasome Inhibitor.
Bhatia S, Krieger V, Groll M, Osko JD, Reßing N, Ahlert H, Borkhardt A, Kurz T, Christianson DW, Hauer J, Hansen FK. Bhatia S, et al. Among authors: kurz t. J Med Chem. 2018 Nov 21;61(22):10299-10309. doi: 10.1021/acs.jmedchem.8b01487. Epub 2018 Nov 8. J Med Chem. 2018. PMID: 30365892 Free PMC article.
Novel reverse thia-analogs of fosmidomycin: Synthesis and antiplasmodial activity.
Lienau C, Gräwert T, Alves Avelar LA, Illarionov B, Held J, Knaab TC, Lungerich B, van Geelen L, Meier D, Geissler S, Cynis H, Riederer U, Buchholz M, Kalscheuer R, Bacher A, Mordmüller B, Fischer M, Kurz T. Lienau C, et al. Among authors: kurz t. Eur J Med Chem. 2019 Nov 1;181:111555. doi: 10.1016/j.ejmech.2019.07.058. Epub 2019 Jul 22. Eur J Med Chem. 2019. PMID: 31382119
312 results