Giménez LE - Search Results

1

DNA immunizations with M2 muscarinic and beta1 adrenergic receptor coding plasmids impair cardiac function in mice.

Giménez LE, Hernández CC, Mattos EC, Brandão IT, Olivieri B, Campelo RP, Araújo-Jorge T, Silva CL, Campos de Carvalho AC, Kurtenbach E. Giménez LE, et al. J Mol Cell Cardiol. 2005 May;38(5):703-14. doi: 10.1016/j.yjmcc.2004.12.009. J Mol Cell Cardiol. 2005. PMID: 15850564

2

Autoantibodies enhance agonist action and binding to cardiac muscarinic receptors in chronic Chagas' disease.

Hernandez CC, Nascimento JH, Chaves EA, Costa PC, Masuda MO, Kurtenbach E, Campos DE Carvalho AC, Gimenez LE. Hernandez CC, et al. Among authors: gimenez le. J Recept Signal Transduct Res. 2008;28(4):375-401. doi: 10.1080/10799890802262319. J Recept Signal Transduct Res. 2008. PMID: 18702010 Free PMC article.

3

Characterization of cardiopulmonary function and cardiac muscarinic and adrenergic receptor density adaptation in C57BL/6 mice with chronic Trypanosoma cruzi infection.

Rocha NN, Garcia S, Giménez LE, Hernández CC, Senra JF, Lima RS, Cyrino F, Bouskela E, Soares MB, Ribeiro dos Santos R, Campos de Carvalho AC. Rocha NN, et al. Among authors: gimenez le. Parasitology. 2006 Dec;133(Pt 6):729-37. doi: 10.1017/S0031182006001193. Epub 2006 Sep 18. Parasitology. 2006. PMID: 16978452

4

The GPCR accessory protein MRAP2 regulates both biased signaling and constitutive activity of the ghrelin receptor GHSR1a.

Rouault AAJ, Rosselli-Murai LK, Hernandez CC, Gimenez LE, Tall GG, Sebag JA. Rouault AAJ, et al. Among authors: gimenez le. Sci Signal. 2020 Jan 7;13(613):eaax4569. doi: 10.1126/scisignal.aax4569. Sci Signal. 2020. PMID: 31911434 Free PMC article.

5

Membrane orientation and oligomerization of the melanocortin receptor accessory protein 2.

Chen V, Bruno AE, Britt LL, Hernandez CC, Gimenez LE, Peisley A, Cone RD, Millhauser GL. Chen V, et al. Among authors: gimenez le. J Biol Chem. 2020 Nov 27;295(48):16370-16379. doi: 10.1074/jbc.RA120.015482. Epub 2020 Sep 17. J Biol Chem. 2020. PMID: 32943551 Free PMC article.

6

Determination of the melanocortin-4 receptor structure identifies Ca²⁺ as a cofactor for ligand binding.

Yu J, Gimenez LE, Hernandez CC, Wu Y, Wein AH, Han GW, McClary K, Mittal SR, Burdsall K, Stauch B, Wu L, Stevens SN, Peisley A, Williams SY, Chen V, Millhauser GL, Zhao S, Cone RD, Stevens RC. Yu J, et al. Among authors: gimenez le. Science. 2020 Apr 24;368(6489):428-433. doi: 10.1126/science.aaz8995. Science. 2020. PMID: 32327598 Free PMC article.

7

A G Protein-biased Designer G Protein-coupled Receptor Useful for Studying the Physiological Relevance of Gq/11-dependent Signaling Pathways.

Hu J, Stern M, Gimenez LE, Wanka L, Zhu L, Rossi M, Meister J, Inoue A, Beck-Sickinger AG, Gurevich VV, Wess J. Hu J, et al. Among authors: gimenez le. J Biol Chem. 2016 Apr 8;291(15):7809-20. doi: 10.1074/jbc.M115.702282. Epub 2016 Feb 5. J Biol Chem. 2016. PMID: 26851281 Free PMC article.

8

Ligand-induced internalization and recycling of the human neuropeptide Y2 receptor is regulated by its carboxyl-terminal tail.

Walther C, Nagel S, Gimenez LE, Mörl K, Gurevich VV, Beck-Sickinger AG. Walther C, et al. Among authors: gimenez le. J Biol Chem. 2010 Dec 31;285(53):41578-90. doi: 10.1074/jbc.M110.162156. Epub 2010 Oct 18. J Biol Chem. 2010. PMID: 20959467 Free PMC article.

9

The melanocortin-3 receptor is a pharmacological target for the regulation of anorexia.

Sweeney P, Bedenbaugh MN, Maldonado J, Pan P, Fowler K, Williams SY, Gimenez LE, Ghamari-Langroudi M, Downing G, Gui Y, Hadley CK, Joy ST, Mapp AK, Simerly RB, Cone RD. Sweeney P, et al. Among authors: gimenez le. Sci Transl Med. 2021 Apr 21;13(590):eabd6434. doi: 10.1126/scitranslmed.abd6434. Sci Transl Med. 2021. PMID: 33883274 Free PMC article.

10

Structure-Based Design of Melanocortin 4 Receptor Ligands Based on the SHU-9119-hMC4R Cocrystal Structure†.

Martin C, Gimenez LE, Williams SY, Jing Y, Wu Y, Hollanders C, Van der Poorten O, Gonzalez S, Van Holsbeeck K, Previti S, Lamouroux A, Zhao S, Tourwé D, Stevens RC, Cone RD, Ballet S. Martin C, et al. Among authors: gimenez le. J Med Chem. 2021 Jan 14;64(1):357-369. doi: 10.1021/acs.jmedchem.0c01620. Epub 2020 Nov 14. J Med Chem. 2021. PMID: 33190475

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