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Page 1
Knockout of cytochrome P450 3A yields new mouse models for understanding xenobiotic metabolism.
van Herwaarden AE, Wagenaar E, van der Kruijssen CM, van Waterschoot RA, Smit JW, Song JY, van der Valk MA, van Tellingen O, van der Hoorn JW, Rosing H, Beijnen JH, Schinkel AH. van Herwaarden AE, et al. Among authors: van tellingen o, van der valk ma, van der hoorn jw, van der kruijssen cm, van waterschoot ra. J Clin Invest. 2007 Nov;117(11):3583-92. doi: 10.1172/JCI33435. J Clin Invest. 2007. PMID: 17975676 Free PMC article.
Midazolam metabolism in cytochrome P450 3A knockout mice can be attributed to up-regulated CYP2C enzymes.
van Waterschoot RA, van Herwaarden AE, Lagas JS, Sparidans RW, Wagenaar E, van der Kruijssen CM, Goldstein JA, Zeldin DC, Beijnen JH, Schinkel AH. van Waterschoot RA, et al. Among authors: van herwaarden ae, van der kruijssen cm. Mol Pharmacol. 2008 Mar;73(3):1029-36. doi: 10.1124/mol.107.043869. Epub 2007 Dec 21. Mol Pharmacol. 2008. PMID: 18156313 Free PMC article.
Organic anion-transporting polypeptide 1B1 mediates transport of Gimatecan and BNP1350 and can be inhibited by several classic ATP-binding cassette (ABC) B1 and/or ABCG2 inhibitors.
Oostendorp RL, van de Steeg E, van der Kruijssen CM, Beijnen JH, Kenworthy KE, Schinkel AH, Schellens JH. Oostendorp RL, et al. Among authors: van der kruijssen cm. Drug Metab Dispos. 2009 Apr;37(4):917-23. doi: 10.1124/dmd.108.024901. Epub 2009 Jan 12. Drug Metab Dispos. 2009. PMID: 19139163
Absence of both cytochrome P450 3A and P-glycoprotein dramatically increases docetaxel oral bioavailability and risk of intestinal toxicity.
van Waterschoot RA, Lagas JS, Wagenaar E, van der Kruijssen CM, van Herwaarden AE, Song JY, Rooswinkel RW, van Tellingen O, Rosing H, Beijnen JH, Schinkel AH. van Waterschoot RA, et al. Among authors: van der kruijssen cm. Cancer Res. 2009 Dec 1;69(23):8996-9002. doi: 10.1158/0008-5472.CAN-09-2915. Epub 2009 Nov 17. Cancer Res. 2009. PMID: 19920203 Free article.
18 results