van Herwaarden AE - Search Results

1

Midazolam and cyclosporin a metabolism in transgenic mice with liver-specific expression of human CYP3A4.

van Herwaarden AE, Smit JW, Sparidans RW, Wagenaar E, van der Kruijssen CM, Schellens JH, Beijnen JH, Schinkel AH. van Herwaarden AE, et al. Among authors: van der kruijssen cm. Drug Metab Dispos. 2005 Jul;33(7):892-5. doi: 10.1124/dmd.105.004721. Epub 2005 Apr 21. Drug Metab Dispos. 2005. PMID: 15845749

2

The breast cancer resistance protein (Bcrp1/Abcg2) restricts exposure to the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.

van Herwaarden AE, Jonker JW, Wagenaar E, Brinkhuis RF, Schellens JH, Beijnen JH, Schinkel AH. van Herwaarden AE, et al. Cancer Res. 2003 Oct 1;63(19):6447-52. Cancer Res. 2003. PMID: 14559835

3

The breast cancer resistance protein BCRP (ABCG2) concentrates drugs and carcinogenic xenotoxins into milk.

Jonker JW, Merino G, Musters S, van Herwaarden AE, Bolscher E, Wagenaar E, Mesman E, Dale TC, Schinkel AH. Jonker JW, et al. Among authors: van herwaarden ae. Nat Med. 2005 Feb;11(2):127-9. doi: 10.1038/nm1186. Epub 2005 Jan 30. Nat Med. 2005. PMID: 15685169 Free article.

4

The breast cancer resistance protein (BCRP/ABCG2) affects pharmacokinetics, hepatobiliary excretion, and milk secretion of the antibiotic nitrofurantoin.

Merino G, Jonker JW, Wagenaar E, van Herwaarden AE, Schinkel AH. Merino G, et al. Among authors: van herwaarden ae. Mol Pharmacol. 2005 May;67(5):1758-64. doi: 10.1124/mol.104.010439. Epub 2005 Feb 11. Mol Pharmacol. 2005. PMID: 15709111

5

Sex-dependent expression and activity of the ATP-binding cassette transporter breast cancer resistance protein (BCRP/ABCG2) in liver.

Merino G, van Herwaarden AE, Wagenaar E, Jonker JW, Schinkel AH. Merino G, et al. Among authors: van herwaarden ae. Mol Pharmacol. 2005 May;67(5):1765-71. doi: 10.1124/mol.105.011080. Epub 2005 Feb 18. Mol Pharmacol. 2005. PMID: 15722455

6

Breast cancer resistance protein (Bcrp1/Abcg2) reduces systemic exposure of the dietary carcinogens aflatoxin B1, IQ and Trp-P-1 but also mediates their secretion into breast milk.

van Herwaarden AE, Wagenaar E, Karnekamp B, Merino G, Jonker JW, Schinkel AH. van Herwaarden AE, et al. Carcinogenesis. 2006 Jan;27(1):123-30. doi: 10.1093/carcin/bgi176. Epub 2005 Jul 6. Carcinogenesis. 2006. PMID: 16000399

7

The function of breast cancer resistance protein in epithelial barriers, stem cells and milk secretion of drugs and xenotoxins.

van Herwaarden AE, Schinkel AH. van Herwaarden AE, et al. Trends Pharmacol Sci. 2006 Jan;27(1):10-6. doi: 10.1016/j.tips.2005.11.007. Epub 2005 Dec 6. Trends Pharmacol Sci. 2006. PMID: 16337280 Review.

8

Multidrug transporter ABCG2/breast cancer resistance protein secretes riboflavin (vitamin B2) into milk.

van Herwaarden AE, Wagenaar E, Merino G, Jonker JW, Rosing H, Beijnen JH, Schinkel AH. van Herwaarden AE, et al. Mol Cell Biol. 2007 Feb;27(4):1247-53. doi: 10.1128/MCB.01621-06. Epub 2006 Dec 4. Mol Cell Biol. 2007. PMID: 17145775 Free PMC article.

9

Knockout of cytochrome P450 3A yields new mouse models for understanding xenobiotic metabolism.

van Herwaarden AE, Wagenaar E, van der Kruijssen CM, van Waterschoot RA, Smit JW, Song JY, van der Valk MA, van Tellingen O, van der Hoorn JW, Rosing H, Beijnen JH, Schinkel AH. van Herwaarden AE, et al. Among authors: van tellingen o, van der valk ma, van der hoorn jw, van der kruijssen cm, van waterschoot ra. J Clin Invest. 2007 Nov;117(11):3583-92. doi: 10.1172/JCI33435. J Clin Invest. 2007. PMID: 17975676 Free PMC article.

10

Midazolam metabolism in cytochrome P450 3A knockout mice can be attributed to up-regulated CYP2C enzymes.

van Waterschoot RA, van Herwaarden AE, Lagas JS, Sparidans RW, Wagenaar E, van der Kruijssen CM, Goldstein JA, Zeldin DC, Beijnen JH, Schinkel AH. van Waterschoot RA, et al. Among authors: van herwaarden ae, van der kruijssen cm. Mol Pharmacol. 2008 Mar;73(3):1029-36. doi: 10.1124/mol.107.043869. Epub 2007 Dec 21. Mol Pharmacol. 2008. PMID: 18156313 Free PMC article.

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