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A missense mutation in KIT kinase domain 1 correlates with imatinib resistance in gastrointestinal stromal tumors.
Chen LL, Trent JC, Wu EF, Fuller GN, Ramdas L, Zhang W, Raymond AK, Prieto VG, Oyedeji CO, Hunt KK, Pollock RE, Feig BW, Hayes KJ, Choi H, Macapinlac HA, Hittelman W, Velasco MA, Patel S, Burgess MA, Benjamin RS, Frazier ML. Chen LL, et al. Cancer Res. 2004 Sep 1;64(17):5913-9. doi: 10.1158/0008-5472.CAN-04-0085. Cancer Res. 2004. PMID: 15342366
Imatinib resistance in gastrointestinal stromal tumors.
Chen LL, Sabripour M, Andtbacka RH, Patel SR, Feig BW, Macapinlac HA, Choi H, Wu EF, Frazier ML, Benjamin RS. Chen LL, et al. Curr Oncol Rep. 2005 Jul;7(4):293-9. doi: 10.1007/s11912-005-0053-6. Curr Oncol Rep. 2005. PMID: 15946589 Review.
Evolution from heterozygous to homozygous KIT mutation in gastrointestinal stromal tumor correlates with the mechanism of mitotic nondisjunction and significant tumor progression.
Chen LL, Holden JA, Choi H, Zhu J, Wu EF, Jones KA, Ward JH, Andtbacka RH, Randall RL, Scaife CL, Hunt KK, Prieto VG, Raymond AK, Zhang W, Trent JC, Benjamin RS, Frazier ML. Chen LL, et al. Mod Pathol. 2008 Jul;21(7):826-36. doi: 10.1038/modpathol.2008.46. Epub 2008 May 16. Mod Pathol. 2008. PMID: 18488000 Free article.
SCF-KIT signaling induces endothelin-3 synthesis and secretion: Thereby activates and regulates endothelin-B-receptor for generating temporally- and spatially-precise nitric oxide to modulate SCF- and or KIT-expressing cell functions.
Chen LL, Zhu J, Schumacher J, Wei C, Ramdas L, Prieto VG, Jimenez A, Velasco MA, Tripp SR, Andtbacka RHI, Gouw L, Rodgers GM, Zhang L, Chan BK, Cassidy PB, Benjamin RS, Leachman SA, Frazier ML. Chen LL, et al. PLoS One. 2017 Sep 7;12(9):e0184154. doi: 10.1371/journal.pone.0184154. eCollection 2017. PLoS One. 2017. PMID: 28880927 Free PMC article.
Exploiting antitumor immunity to overcome relapse and improve remission duration.
Chen LL, Chen X, Choi H, Sang H, Chen LC, Zhang H, Gouw L, Andtbacka RH, Chan BK, Rodesch CK, Jimenez A, Cano P, Jones KA, Oyedeji CO, Martins T, Hill HR, Schumacher J, Willmore C, Scaife CL, Ward JH, Morton K, Randall RL, Lazar AJ, Patel S, Trent JC, Frazier ML, Lin P, Jensen P, Benjamin RS. Chen LL, et al. Among authors: chen lc, chen x. Cancer Immunol Immunother. 2012 Jul;61(7):1113-24. doi: 10.1007/s00262-011-1185-1. Epub 2011 Dec 24. Cancer Immunol Immunother. 2012. PMID: 22198309 Free PMC article. Clinical Trial.
1,750 results